Dr. Percival Yang-Ting Chen, Ph.D.

Percy was born in Taiwan. He received his B.S. degree in Chemistry from the National Taiwan University in 2013 while working in the laboratory of Prof. Yuan-Chung Cheng. In 2019, he received his Ph.D. in Chemistry from the Massachusetts Institute of Technology under Prof. Catherine L. Drennan. His graduate research focused on the structural and biochemical characterization of metalloproteins and thiamine diphosphate-dependent enzymes. He joined the Moore Lab in July 2019.

Publications (denotes equal contributions)

9. Chen, P.Y.-T., DeColli, A.A., Freel Meyers, C.L., Drennan, C.L. (2019) X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate, J. Biol. Chem. paper in press. DOI:10.1074/jbc.RA119.009321


8. Chen, P.Y.-T., Li, B., Drennan, C.L., Elliott, S.J. (2019), A reverse TCA cycle 2‑oxoacid:ferredoxin oxidoreductase that makes C-C bonds from CO2Joule, 3, 595-611.PMCID: PMC6508887; DOI: 10.1016/j.joule.2018.12.006


7. Chen, P.Y.-T., Funk, M.A., Brignole, E.J., Drennan, C.L. (2018) Disruption of an oligomeric interface prevents allosteric inhibition of Escherichiacoli class Ia ribonucleotide reductase, J. Biol. Chem., 293, 10404-10412. PMCID: PMC6028975; DOI: 10.1074/jbc.RA118.002569


6. Chen, P.Y.-T., Aman, H., Can, M., Ragsdale, S.W., Drennan, C.L. (2018) Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoaceticaProc. Natl. Acad. Sci. USA, 115,  3846-3851. PMCID: PMC5899475; DOI: 10.1073/pnas.1722329115


5. Gibson, M.I., ChenP.Y.-T., Drennan, C.L. (2016) A structural phylogeny for understanding 2‑oxoacid oxidoreductase function, Curr. Opin. Struct. Biol.,41, 54-61. PMCID: PMC5381805; DOI: 10.1016/j.sbi.2016.05.011


4. Chen, P.Y.-T., Wittenborn, E.C., Drennan, C.L. (2016) Waltzing around cofactors, eLife, 5, e13977. PMCID: PMC4758945; DOI: 10.7554/eLife.13977


3. Gibson, M.I., ChenP.Y.-T., Johnson, A.C., Pierce, E., Can, M., Ragsdale, S.W., Drennan, C.L. (2016) One‑carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography, Proc. Natl. Acad. Sci. USA, 113, 320-325. PMCID: PMC4720323; DOI: 10.1073/pnas.1518537113


2. Zimanyi, C.M., Chen, P.Y.-T., Kang, G., Funk, M.A., Drennan, C.L. (2016) Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia colieLife, 5, e07141. PMCID: PMC4728125 DOI: 10.7554/eLife.07141


1. Jost, M., Fernández-Zapata, J., Polanco, M.C., Ortiz-Guerrero, J.M., Chen, P.Y.-T., Kang, G., Padmanabhan, S., Elías-Arnanz, M., Drennan, C.L. (2015) Structural basis for gene regulation by a B12-dependent photoreceptor, Nature, 526, 536-541. PMCID: PMC4634937; DOI: 10.1038/nature14950