BRADLEY MOORE
Professor
CTR FOR MARINE BIOTEC & BIOMED
Research Interests
- Marine Biomedicine and Biotechnology
- Microbial Genomics and Metabolomics
- Natural Product Drug Discovery
- Natural Toxins and Pollutants
- Synthetic Biology
Degrees
- B.S., University of Hawaii
- PhD, University of Washington
- Postdoc, University of Zurich
Recent Publications
9129767 IWNPIQDK apa 5 date desc year Moore 265 https://bsmoore.scrippsprofiles.ucsd.edu/wp-content/plugins/zotpress/
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Brunson, J. K., Thukral, M., Ryan, J. P., Anderson, C. R., Kolody, B. C., James, C. C., Chavez, F. P., Leaw, C. P., Rabines, A. J., Venepally, P., Fussy, Z., Zheng, H., Kudela, R. M., Smith, G. J., Moore, B. S., & Allen, A. E. (2024). Molecular forecasting of domoic acid during a pervasive toxic diatom bloom. Proceedings of the National Academy of Sciences, 121(40). https://doi.org/10.1073/pnas.2319177121
Adak, S., Ye, N., Calderone, L. A., Duan, M., Lubeck, W., Schäfer, R. J. B., Lukowski, A. L., Houk, K. N., Pandelia, M.-E., Drennan, C. L., & Moore, B. S. (2024). A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile. Nature Chemistry. https://doi.org/10.1038/s41557-024-01603-z
Fallon, T. R., Shende, V. V., Wierzbicki, I. H., Pendleton, A. L., Watervoot, N. F., Auber, R. P., Gonzalez, D. J., Wisecaver, J. H., & Moore, B. S. (2024). Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins. Science, 385(6709), 671–678. https://doi.org/10.1126/science.ado3290
Love, A. C., Purdy, T. N., Hubert, F. M., Kirwan, E. J., Holland, D. C., & Moore, B. S. (2024). Discovery of Latent Cannabichromene Cyclase Activity in Marine Bacterial Flavoenzymes. ACS Synthetic Biology, acssynbio.4c00051. https://doi.org/10.1021/acssynbio.4c00051
Steele, T. S., Burkhardt, I., Moore, M. L., De Rond, T., Bone, H. K., Barry, K., Bunting, V. M., Grimwood, J., Handley, L. H., Rajasekar, S., Talag, J., Michael, T. P., & Moore, B. S. (2024). Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases. ACS Chemical Biology, 19(1), 185–192. https://doi.org/10.1021/acschembio.3c00627
