BRADLEY MOORE

Professor
CTR FOR MARINE BIOTEC & BIOMED

Research Interests

  • Marine Biomedicine and Biotechnology
  • Microbial Genomics and Metabolomics
  • Natural Product Drug Discovery
  • Natural Toxins and Pollutants
  • Synthetic Biology

Degrees

  • B.S., University of Hawaii
  • PhD, University of Washington
  • Postdoc, University of Zurich

Recent Publications

Lima, S. T., Fallon, T. R., Cordoza, J. L., Chekan, J. R., Delbaje, E., Hopiavuori, A. R., Alvarenga, D. O., Wood, S. M., Luhavaya, H., Baumgartner, J. T., Dörr, F. A., Etchegaray, A., Pinto, E., McKinnie, S. M. K., Fiore, M. F., & Moore, B. S. (2022). Biosynthesis of Guanitoxin Enables Global Environmental Detection in Freshwater Cyanobacteria. Journal of the American Chemical Society, 144(21), 9372–9379. https://doi.org/10.1021/jacs.2c01424
Burkhardt, I., de Rond, T., Chen, P. Y. T., & Moore, B. S. (2022). Ancient plant-like terpene biosynthesis in corals. Nature Chemical Biology, 18(6), 664-+. https://doi.org/10.1038/s41589-022-01026-2
Bauman, K. D., Shende, V. V., Chen, P. Y. T., Trivella, D. B. B., Gulder, T. A. M., Vellalath, S., Romo, D., & Moore, B. S. (2022). Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead. Nature Chemical Biology, 25. https://doi.org/10.1038/s41589-022-00993-w
Purdy, T. N., Moore, B. S., & Lukowski, A. L. (2022). Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis. Journal of Natural Products, 85(3), 688–701. https://doi.org/10.1021/acs.jnatprod.1c01026
Steele, T. S., Brunson, J. K., Maeno, Y., Terada, R., Allen, A. E., Yotsu-Yamashita, M., Chekan, J. R., & Moore, B. S. (2022). Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production. Proceedings of the National Academy of Sciences of the United States of America, 119(6). https://doi.org/10.1073/pnas.2117407119
Adak, S., Lukowski, A. L., Schafer, R. J. B., & Moore, B. S. (2022). From tryptophan to toxin: Nature’s convergent biosynthetic strategy to aetokthonotoxin. Journal of the American Chemical Society, 144(7), 2861–2866. https://doi.org/10.1021/jacs.1c12778
Yahiaoui, O., Murray, L. A. M., Zhao, F. Y., Moore, B. S., Houk, K. N., Liu, F., & George, J. H. (2022). A Diazo-Hooker reaction, inspired by the biosynthesis of azamerone. Organic Letters, 6. https://doi.org/10.1021/acs.orglett.1c03810
Zheng, J., Antrobus, S., Feng, W., Purdy, T. N., Moore, B. S., & Pessah, I. N. (2021). Marine and Anthropogenic Bromopyrroles Alter Cellular Ca2+ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca2+-ATPase. Environmental Science & Technology, 55(23), 16023–16033. https://doi.org/10.1021/acs.est.1c05214
Bauman, K. D., Butler, K. S., Moore, B. S., & Chekan, J. R. (2021). Genome mining methods to discover bioactive natural products. Natural Product Reports, 38(11), 2100–2129. https://doi.org/10.1039/d1np00032b
Daniels, P. N., Lee, H., Splain, R. A., Ting, C. P., Zhu, L. Y., Zhao, X. L., Moore, B. S., & van der Donk, W. A. (2021). A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor. Nature Chemistry, 10. https://doi.org/10.1038/s41557-021-00802-2
Medema, M. H., de Rond, T., & Moore, B. S. (2021). Mining genomes to illuminate the specialized chemistry of life. Nature Reviews Genetics, 19. https://doi.org/10.1038/s41576-021-00363-7
de Rond, T., Asay, J. E., & Moore, B. S. (2021). Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase. Nature Chemical Biology, 12. https://doi.org/10.1038/s41589-021-00808-4
Purdy, T. N., Kim, M. C., Cullum, R., Fenical, W., & Moore, B. S. (2021). Discovery and biosynthesis of tetrachlorizine reveals enzymatic benzylic dehydrogenation via an ortho-quinone methide. Journal of the American Chemical Society, 143(10), 3682–3686. https://doi.org/10.1021/jacs.0c12415
Adak, S., & Moore, B. S. (2021). Cryptic halogenation reactions in natural product biosynthesis. Natural Product Reports. https://doi.org/10.1039/d1np00010a
Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., … van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. https://doi.org/10.1038/s41589-020-00724-z
Kudo, Y., Awakawa, T., Du, Y. L., Jordan, P. A., Creamer, K. E., Jensen, P. R., Linington, R. G., Ryan, K. S., & Moore, B. S. (2020). Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products. Acs Chemical Biology, 15(12), 3253–3261. https://doi.org/10.1021/acschembio.0c00824
Chekan, J. R., Fallon, T. R., & Moore, B. S. (2020). Biosynthesis of marine toxins. Current Opinion in Chemical Biology, 59, 119–129. https://doi.org/10.1016/j.cbpa.2020.06.009
Murray, L. A. M., McKinnie, S. M. K., Moore, B. S., & George, J. H. (2020). Meroterpenoid natural products fromStreptomycesbacteria - the evolution of chemoenzymatic syntheses. Natural Product Reports, 37(10), 1334–1366. https://doi.org/10.1039/d0np00018c
Alker, A. T., Delherbe, N., Purdy, T. N., Moore, B. S., & Shikuma, N. J. (2020). Genetic examination of the marine bacteriumPseudoalteromonas luteoviolaceaand effects of its metamorphosis-inducing factors. Environmental Microbiology. https://doi.org/10.1111/1462-2920.15211
Podell, S., Blanton, J. M., Oliver, A., Schorn, M. A., Agarwal, V., Biggs, J. S., Moore, B. S., & Allen, E. E. (2020). A genomic view of trophic and metabolic diversity in clade-specific Lamellodysidea sponge microbiomes. Microbiome, 8. https://doi.org/10.21203/rs.2.17204/v1
Zhang, J. J., & Moore, B. S. (2020). Site-directed mutagenesis of large biosynthetic gene clusters via oligonucleotide recombineering and CRISPR/Cas9 targeting. Acs Synthetic Biology, 9(7), 1917–1922. https://doi.org/10.1021/acssynbio.0c00265
Chekan, O. R., McKinnie, S. M. K., Noel, J. P., & Moore, B. S. (2020). Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12799–12805. https://doi.org/10.1073/pnas.2001325117
Sigrist, R., Luhavaya, H., McKinnie, S. M. K., da Silva, A. F., Jurberg, I. D., Moore, B. S., & de Oliveira, L. G. (2020). Nonlinear biosynthetic assembly of alpiniamide by a hybrid cis/trans-AT PKS-NRPS. Acs Chemical Biology, 15(4), 1067–1077. https://doi.org/10.1021/acschembio.0c00081
Tang, X. Y., Kudo, Y., Baker, J. L., LaBonte, S., Jordan, P. A., McKinnie, S. M. K., Guo, J., Huan, T., Moore, B. S., & Edlund, A. (2020). Cariogenic Streptococcus mutans produces tetramic acid strain-specific antibiotics that impair commensal colonization. Acs Infectious Diseases, 6(4), 563–571. https://doi.org/10.1021/acsinfecdis.9b00365
Fiore, M. F., de Lima, S. T., Carmichael, W. W., McKinnie, S. M. K., Chekan, J. R., & Moore, B. S. (2020). Guanitoxin, re-naming a cyanobacterial organophosphate toxin. Harmful Algae, 92. https://doi.org/10.1016/j.hal.2019.101737
Zhang, J. J., Tang, X. Y., Huan, T., Ross, A. C., & Moore, B. S. (2020). Pass-back chain extension expands multimodular assembly line biosynthesis. Nature Chemical Biology, 16(1), 42-+. https://doi.org/10.1038/s41589-019-0385-4
Chekan, J. R., Lee, G. Y., El Gamal, A., Purdy, T. N., Houk, K. N., & Moore, B. S. (2019). Bacterial tetrabromopyrrole debrominase shares a reductive dehalogenation strategy with human thyroid deiodinase. Biochemistry, 58(52), 5329–5338. https://doi.org/10.1021/acs.biochem.9b00318
Li, Z. R., Li, J., Cai, W. L., Lai, J. Y. H., McKinnie, S. M. K., Zhang, W. P., Moore, B. S., Zhang, W. J., & Qian, P. Y. (2019). Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nature Chemistry, 11(10), 880–889. https://doi.org/10.1038/s41557-019-0317-7
Zhang, J. J., Tang, X. Y., & Moore, B. S. (2019). Genetic platforms for heterologous expression of microbial natural products. Natural Product Reports, 36(9), 1313–1332. https://doi.org/10.1039/c9np00025a
Valiadi, M., de Rond, T., Amorim, A., Gittins, J. R., Gubili, C., Moore, B. S., Iglesias-Rodriguez, M. D., & Latz, M. I. (2019). Molecular and biochemical basis for the loss of bioluminescence in the dinoflagellate Noctiluca scintillans along the west coast of the USA. Limnology and Oceanography. https://doi.org/10.1002/lno.11309
Chekan, J. R., McKinnie, S. M. K., Moore, M. L., Poplawski, S. G., Michael, T. P., & Moore, B. S. (2019). Scalable biosynthesis of the seaweed neurochemical, kainic acid. Angewandte Chemie-International Edition, 58(25), 8454–8457. https://doi.org/10.1002/anie.201902910
Schorn, M. A., Jordan, P. A., Podell, S., Blanton, J. M., Agarwal, V., Biggs, J. S., Allen, E. E., & Moore, B. S. (2019). Comparative genomics of cyanobacterial symbionts reveals distinct, specialized metabolism in tropical Dysideidae sponges. Mbio, 10. https://doi.org/10.1128/mBio.00821-19
Luhavaya, H., Sigrist, R., Chekan, J. R., McKinnie, S. M. K., & Moore, B. S. (2019). Biosynthesis of l-4-chlorokynurenine, an antidepressant prodrug and a non-proteinogenic amino acid found in lipopeptide antibiotics. Angewandte Chemie-International Edition, 58(25), 8394–8399. https://doi.org/10.1002/anie.201901571
Bauman, K. D., Li, J., Murata, K., Mantovani, S. M., Dahesh, S., Nizet, V., Luhavaya, H., & Moore, B. S. (2019). Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry. Cell Chemical Biology, 26(5), 724-+. https://doi.org/10.1016/j.chembiol.2019.02.004
Walsh, C. T., & Moore, B. S. (2019). Enzymatic cascade reactions in biosynthesis. Angewandte Chemie-International Edition, 58(21), 6846–6879. https://doi.org/10.1002/anie.201807844
Busch, J., Agarwal, V., Schorn, M., Machado, H., Moore, B. S., Rouse, G. W., Gram, L., & Jensen, P. R. (2019). Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas. Environmental Microbiology, 21(5), 1575–1585. https://doi.org/10.1111/1462-2920.14532
Rothe, M. L., Li, J., Garibay, E., Moore, B. S., & McKinnie, S. M. K. (2019). Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives. Organic & Biomolecular Chemistry, 17(13), 3416–3423. https://doi.org/10.1039/c8ob03109f
Thapa, H. R., Robbins, J. M., Moore, B. S., & Agarwal, V. (2019). Insights into thiotemplated pyrrole biosynthesis gained from the crystal structure of flavin-dependent oxidase in complex with carrier protein. Biochemistry, 58(7), 918–929. https://doi.org/10.1021/acs.biochem.8b01177
McAlpine, J. B., Chen, S. N., Kutateladze, A., MacMillan, J. B., Appendino, G., Barison, A., Beniddir, M. A., Biavatti, M. W., Bluml, S., Boufridi, A., Butler, M. S., Capon, R. J., Choi, Y. H., Coppage, D., Crews, P., Crimmins, M. T., Csete, M., Dewapriya, P., Egan, J. M., … Pauli, G. F. (2019). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36(1), 35–107. https://doi.org/10.1039/c7np00064b
Zhang, J. J., Yamanaka, K., Tang, X. Y., & Moore, B. S. (2019). Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination. In A. K. Shukla (Ed.), Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Pt A (Vol. 621, pp. 87–110). Elsevier Academic Press Inc.
McKinnie, S. M. K., Miles, Z. D., Jordan, P. A., Awakawa, T., Pepper, H. P., Murray, L. A. M., George, J. H., & Moore, B. S. (2018). Total enzyme syntheses of napyradiomycins A1 and B1. Journal of the American Chemical Society, 140(51), 17840–17845. https://doi.org/10.1021/jacs.8b10134
Schlawis, C., Kern, S., Kudo, Y., Grunenberg, J., Moore, B. S., & Schulz, S. (2018). Structural elucidation of trace components combining GC/MS, GC/IR, DFT-calculation and synthesis-salinilactones, unprecedented bicyclic lactones from Salinispora bacteria. Angewandte Chemie-International Edition, 57(45), 14921–14925. https://doi.org/10.1002/anie.201807923
Whalen, K. E., Kirby, C., Nicholson, R. M., O’Reilly, M., Moore, B. S., & Harvey, E. L. (2018). The chemical cue tetrabromopyrrole induces rapid cellular stress and mortality in phytoplankton. Scientific Reports, 8. https://doi.org/10.1038/s41598-018-33945-3
Podell, S., Blanton, J. M., Neu, A., Agarwal, V., Biggs, J. S., Moore, B. S., & Allen, E. E. (2018). Pangenomic comparison of globally distributed Poribacteria associated with sponge hosts and marine particles. The ISME Journal. https://doi.org/10.1038/s41396-018-0292-9
Zhang, J. J., Moore, B. S., & Tang, X. Y. (2018). Engineering Salinispora tropica for heterologous expression of natural product biosynthetic gene clusters. Applied Microbiology and Biotechnology, 102(19), 8437–8446. https://doi.org/10.1007/s00253-018-9283-z
Brunson, J. K., McKinnie, S. M. K., Chekan, J. R., McCrow, J. P., Miles, Z. D., Bertrand, E. M., Bielinski, V. A., Luhavaya, H., Obornik, M., Smith, G. J., Hutchins, D. A., Allen, A. E., & Moore, B. S. (2018). Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom. Science, 361(6409), 1356-+. https://doi.org/10.1126/science.aau0382
Murray, L. A. M., McKinnie, S. M. K., Pepper, H. P., Erni, R., Miles, Z. D., Cruickshank, M. C., Lopez-Perez, B., Moore, B. S., & George, J. H. (2018). Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products. Angewandte Chemie-International Edition, 57(34), 11009–11014. https://doi.org/10.1002/anie.201804351
Zheng, J., McKinnie, S. M. K., El Gama, A., Fengit, W., Dong, Y., Agarwal, V., Fenical, W., Kumar, A., Cao, Z. Y., Moore, B. S., & Pessah, I. N. (2018). Organohalogens naturally biosynthesized in marine environments and produced as disinfection byproducts alter sarco/endoplasmic reticulum ca2+ dynamics. Environmental Science & Technology, 52(9), 5469–5478. https://doi.org/10.1021/acs.est.8b00512
Saleem-Batcha, R., Stull, F., Sanders, J. N., Moore, B. S., Palfey, B. A., Houk, K. N., & Teufel, R. (2018). Enzymatic control of dioxygen binding and functionalization of the flavin cofactor. Proceedings of the National Academy of Sciences of the United States of America, 115(19), 4909–4914. https://doi.org/10.1073/pnas.1801189115
Moore, B. S. (2018). Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis. Synlett, 29(4), 401–409. https://doi.org/10.1055/s-0036-1590919