Chen, P. Y.-T., Adak, S., Chekan, J. R., Liscombe, D. K., Miyanaga, A., Bernhardt, P., Diethelm, S., Fielding, E. N., George, J. H., Miles, Z. D., Murray, L. A. M., Steele, T. S., Winter, J. M., Noel, J. P., & Moore, B. S. (2022). Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry, 61(17), 1844–1852.
Lima, S. T., Fallon, T. R., Cordoza, J. L., Chekan, J. R., Delbaje, E., Hopiavuori, A. R., Alvarenga, D. O., Wood, S. M., Luhavaya, H., Baumgartner, J. T., Dörr, F. A., Etchegaray, A., Pinto, E., McKinnie, S. M. K., Fiore, M. F., & Moore, B. S. (2022). Biosynthesis of Guanitoxin Enables Global Environmental Detection in Freshwater Cyanobacteria. Journal of the American Chemical Society, 144(21), 9372–9379.
Burkhardt, I., de Rond, T., Chen, P. Y. T., & Moore, B. S. (2022). Ancient plant-like terpene biosynthesis in corals. Nature Chemical Biology, 18(6), 664-+.
Bauman, K. D., Shende, V. V., Chen, P. Y. T., Trivella, D. B. B., Gulder, T. A. M., Vellalath, S., Romo, D., & Moore, B. S. (2022). Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead. Nature Chemical Biology, 25.
Purdy, T. N., Moore, B. S., & Lukowski, A. L. (2022). Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis. Journal of Natural Products, 85(3), 688–701.
Steele, T. S., Brunson, J. K., Maeno, Y., Terada, R., Allen, A. E., Yotsu-Yamashita, M., Chekan, J. R., & Moore, B. S. (2022). Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production. Proceedings of the National Academy of Sciences of the United States of America, 119(6).
Adak, S., Lukowski, A. L., Schafer, R. J. B., & Moore, B. S. (2022). From tryptophan to toxin: Nature’s convergent biosynthetic strategy to aetokthonotoxin. Journal of the American Chemical Society, 144(7), 2861–2866.
Yahiaoui, O., Murray, L. A. M., Zhao, F. Y., Moore, B. S., Houk, K. N., Liu, F., & George, J. H. (2022). A Diazo-Hooker reaction, inspired by the biosynthesis of azamerone. Organic Letters, 6.
Klau, L. J., Podell, S., Creamer, K. E., Demko, A. M., Singh, H. W., Allen, E. E., Moore, B. S., Ziemert, N., Letzel, A. C., & Jensen, P. R. (2022). The Natural Product Domain Seeker version 2 (NaPDoS2) webtool relates ketosynthase phylogeny to biosynthetic function. Journal of Biological Chemistry, 298(10), 102480.
Zheng, J., Antrobus, S., Feng, W., Purdy, T. N., Moore, B. S., & Pessah, I. N. (2021). Marine and Anthropogenic Bromopyrroles Alter Cellular Ca2+ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca2+-ATPase. Environmental Science & Technology, 55(23), 16023–16033.
Bauman, K. D., Butler, K. S., Moore, B. S., & Chekan, J. R. (2021). Genome mining methods to discover bioactive natural products. Natural Product Reports, 38(11), 2100–2129.
Daniels, P. N., Lee, H., Splain, R. A., Ting, C. P., Zhu, L. Y., Zhao, X. L., Moore, B. S., & van der Donk, W. A. (2021). A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor. Nature Chemistry, 10.
Medema, M. H., de Rond, T., & Moore, B. S. (2021). Mining genomes to illuminate the specialized chemistry of life. Nature Reviews Genetics, 19.
de Rond, T., Asay, J. E., & Moore, B. S. (2021). Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase. Nature Chemical Biology, 12.
Purdy, T. N., Kim, M. C., Cullum, R., Fenical, W., & Moore, B. S. (2021). Discovery and biosynthesis of tetrachlorizine reveals enzymatic benzylic dehydrogenation via an ortho-quinone methide. Journal of the American Chemical Society, 143(10), 3682–3686.
Adak, S., & Moore, B. S. (2021). Cryptic halogenation reactions in natural product biosynthesis. Natural Product Reports.
Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., … van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology.
Kudo, Y., Awakawa, T., Du, Y. L., Jordan, P. A., Creamer, K. E., Jensen, P. R., Linington, R. G., Ryan, K. S., & Moore, B. S. (2020). Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products. Acs Chemical Biology, 15(12), 3253–3261.
Chekan, J. R., Fallon, T. R., & Moore, B. S. (2020). Biosynthesis of marine toxins. Current Opinion in Chemical Biology, 59, 119–129.
Murray, L. A. M., McKinnie, S. M. K., Moore, B. S., & George, J. H. (2020). Meroterpenoid natural products fromStreptomycesbacteria - the evolution of chemoenzymatic syntheses. Natural Product Reports, 37(10), 1334–1366.
Alker, A. T., Delherbe, N., Purdy, T. N., Moore, B. S., & Shikuma, N. J. (2020). Genetic examination of the marine bacteriumPseudoalteromonas luteoviolaceaand effects of its metamorphosis-inducing factors. Environmental Microbiology.
Podell, S., Blanton, J. M., Oliver, A., Schorn, M. A., Agarwal, V., Biggs, J. S., Moore, B. S., & Allen, E. E. (2020). A genomic view of trophic and metabolic diversity in clade-specific Lamellodysidea sponge microbiomes. Microbiome, 8.
Zhang, J. J., & Moore, B. S. (2020). Site-directed mutagenesis of large biosynthetic gene clusters via oligonucleotide recombineering and CRISPR/Cas9 targeting. Acs Synthetic Biology, 9(7), 1917–1922.
Chekan, O. R., McKinnie, S. M. K., Noel, J. P., & Moore, B. S. (2020). Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12799–12805.
Sigrist, R., Luhavaya, H., McKinnie, S. M. K., da Silva, A. F., Jurberg, I. D., Moore, B. S., & de Oliveira, L. G. (2020). Nonlinear biosynthetic assembly of alpiniamide by a hybrid cis/trans-AT PKS-NRPS. Acs Chemical Biology, 15(4), 1067–1077.
Tang, X. Y., Kudo, Y., Baker, J. L., LaBonte, S., Jordan, P. A., McKinnie, S. M. K., Guo, J., Huan, T., Moore, B. S., & Edlund, A. (2020). Cariogenic Streptococcus mutans produces tetramic acid strain-specific antibiotics that impair commensal colonization. Acs Infectious Diseases, 6(4), 563–571.
Fiore, M. F., de Lima, S. T., Carmichael, W. W., McKinnie, S. M. K., Chekan, J. R., & Moore, B. S. (2020). Guanitoxin, re-naming a cyanobacterial organophosphate toxin. Harmful Algae, 92.
Zhang, J. J., Tang, X. Y., Huan, T., Ross, A. C., & Moore, B. S. (2020). Pass-back chain extension expands multimodular assembly line biosynthesis. Nature Chemical Biology, 16(1), 42-+.
Chekan, J. R., Lee, G. Y., El Gamal, A., Purdy, T. N., Houk, K. N., & Moore, B. S. (2019). Bacterial tetrabromopyrrole debrominase shares a reductive dehalogenation strategy with human thyroid deiodinase. Biochemistry, 58(52), 5329–5338.
Li, Z. R., Li, J., Cai, W. L., Lai, J. Y. H., McKinnie, S. M. K., Zhang, W. P., Moore, B. S., Zhang, W. J., & Qian, P. Y. (2019). Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nature Chemistry, 11(10), 880–889.
Zhang, J. J., Tang, X. Y., & Moore, B. S. (2019). Genetic platforms for heterologous expression of microbial natural products. Natural Product Reports, 36(9), 1313–1332.
Valiadi, M., de Rond, T., Amorim, A., Gittins, J. R., Gubili, C., Moore, B. S., Iglesias-Rodriguez, M. D., & Latz, M. I. (2019). Molecular and biochemical basis for the loss of bioluminescence in the dinoflagellate Noctiluca scintillans along the west coast of the USA. Limnology and Oceanography.
Schorn, M. A., Jordan, P. A., Podell, S., Blanton, J. M., Agarwal, V., Biggs, J. S., Allen, E. E., & Moore, B. S. (2019). Comparative genomics of cyanobacterial symbionts reveals distinct, specialized metabolism in tropical Dysideidae sponges. Mbio, 10.
Chekan, J. R., McKinnie, S. M. K., Moore, M. L., Poplawski, S. G., Michael, T. P., & Moore, B. S. (2019). Scalable biosynthesis of the seaweed neurochemical, kainic acid. Angewandte Chemie-International Edition, 58(25), 8454–8457.
Luhavaya, H., Sigrist, R., Chekan, J. R., McKinnie, S. M. K., & Moore, B. S. (2019). Biosynthesis of l-4-chlorokynurenine, an antidepressant prodrug and a non-proteinogenic amino acid found in lipopeptide antibiotics. Angewandte Chemie-International Edition, 58(25), 8394–8399.
Busch, J., Agarwal, V., Schorn, M., Machado, H., Moore, B. S., Rouse, G. W., Gram, L., & Jensen, P. R. (2019). Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas. Environmental Microbiology, 21(5), 1575–1585.
Bauman, K. D., Li, J., Murata, K., Mantovani, S. M., Dahesh, S., Nizet, V., Luhavaya, H., & Moore, B. S. (2019). Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry. Cell Chemical Biology, 26(5), 724-+.
Walsh, C. T., & Moore, B. S. (2019). Enzymatic cascade reactions in biosynthesis. Angewandte Chemie-International Edition, 58(21), 6846–6879.
Rothe, M. L., Li, J., Garibay, E., Moore, B. S., & McKinnie, S. M. K. (2019). Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives. Organic & Biomolecular Chemistry, 17(13), 3416–3423.
Thapa, H. R., Robbins, J. M., Moore, B. S., & Agarwal, V. (2019). Insights into thiotemplated pyrrole biosynthesis gained from the crystal structure of flavin-dependent oxidase in complex with carrier protein. Biochemistry, 58(7), 918–929.
McAlpine, J. B., Chen, S. N., Kutateladze, A., MacMillan, J. B., Appendino, G., Barison, A., Beniddir, M. A., Biavatti, M. W., Bluml, S., Boufridi, A., Butler, M. S., Capon, R. J., Choi, Y. H., Coppage, D., Crews, P., Crimmins, M. T., Csete, M., Dewapriya, P., Egan, J. M., … Pauli, G. F. (2019). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36(1), 35–107.
Zhang, J. J., Yamanaka, K., Tang, X. Y., & Moore, B. S. (2019). Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination. In A. K. Shukla (Ed.), Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Pt A (Vol. 621, pp. 87–110). Elsevier Academic Press Inc.
McKinnie, S. M. K., Miles, Z. D., Jordan, P. A., Awakawa, T., Pepper, H. P., Murray, L. A. M., George, J. H., & Moore, B. S. (2018). Total enzyme syntheses of napyradiomycins A1 and B1. Journal of the American Chemical Society, 140(51), 17840–17845.
Schlawis, C., Kern, S., Kudo, Y., Grunenberg, J., Moore, B. S., & Schulz, S. (2018). Structural elucidation of trace components combining GC/MS, GC/IR, DFT-calculation and synthesis-salinilactones, unprecedented bicyclic lactones from Salinispora bacteria. Angewandte Chemie-International Edition, 57(45), 14921–14925.
Whalen, K. E., Kirby, C., Nicholson, R. M., O’Reilly, M., Moore, B. S., & Harvey, E. L. (2018). The chemical cue tetrabromopyrrole induces rapid cellular stress and mortality in phytoplankton. Scientific Reports, 8.
Podell, S., Blanton, J. M., Neu, A., Agarwal, V., Biggs, J. S., Moore, B. S., & Allen, E. E. (2018). Pangenomic comparison of globally distributed Poribacteria associated with sponge hosts and marine particles. The ISME Journal.
Zhang, J. J., Moore, B. S., & Tang, X. Y. (2018). Engineering Salinispora tropica for heterologous expression of natural product biosynthetic gene clusters. Applied Microbiology and Biotechnology, 102(19), 8437–8446.
Brunson, J. K., McKinnie, S. M. K., Chekan, J. R., McCrow, J. P., Miles, Z. D., Bertrand, E. M., Bielinski, V. A., Luhavaya, H., Obornik, M., Smith, G. J., Hutchins, D. A., Allen, A. E., & Moore, B. S. (2018). Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom. Science, 361(6409), 1356-+.
Murray, L. A. M., McKinnie, S. M. K., Pepper, H. P., Erni, R., Miles, Z. D., Cruickshank, M. C., Lopez-Perez, B., Moore, B. S., & George, J. H. (2018). Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products. Angewandte Chemie-International Edition, 57(34), 11009–11014.
Zheng, J., McKinnie, S. M. K., El Gama, A., Fengit, W., Dong, Y., Agarwal, V., Fenical, W., Kumar, A., Cao, Z. Y., Moore, B. S., & Pessah, I. N. (2018). Organohalogens naturally biosynthesized in marine environments and produced as disinfection byproducts alter sarco/endoplasmic reticulum ca2+ dynamics. Environmental Science & Technology, 52(9), 5469–5478.