220 publications
2020
- Kudo, Y., Awakawa, T., Du, Y. L., Jordan, P. A., Creamer, K. E., Jensen, P. R., ... Moore, B. S. (2020). Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products. Acs Chemical Biology, 15(12), 3253-3261. doi: 10.1021/acschembio.0c00824
- Chekan, J. R., Fallon, T. R., & Moore, B. S. (2020). Biosynthesis of marine toxins. Current Opinion in Chemical Biology, 59, 119-129. doi: 10.1016/j.cbpa.2020.06.009
- Murray, L. A. M., McKinnie, S. M. K., Moore, B. S., & George, J. H. (2020). Meroterpenoid natural products fromStreptomycesbacteria - the evolution of chemoenzymatic syntheses. Natural Product Reports, 37(10), 1334-1366. doi: 10.1039/d0np00018c
- Alker, A. T., Delherbe, N., Purdy, T. N., Moore, B. S., & Shikuma, N. J. (2020). Genetic examination of the marine bacteriumPseudoalteromonas luteoviolaceaand effects of its metamorphosis-inducing factors. Environmental Microbiology. doi: 10.1111/1462-2920.15211
- Zhang, J. J., & Moore, B. S. (2020). Site-Directed Mutagenesis of Large Biosynthetic Gene Clusters via Oligonucleotide Recombineering and CRISPR/Cas9 Targeting. Acs Synthetic Biology, 9(7), 1917-1922. doi: 10.1021/acssynbio.0c00265
- Podell, S., Blanton, J. M., Oliver, A., Schorn, M. A., Agarwal, V., Biggs, J. S., ... Allen, E. E. (2020). A genomic view of trophic and metabolic diversity in clade-specific Lamellodysidea sponge microbiomes. Microbiome, 8. doi: 10.21203/rs.2.17204/v1
- Chekan, O. R., McKinnie, S. M. K., Noel, J. P., & Moore, B. S. (2020). Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12799-12805. doi: 10.1073/pnas.2001325117
- Sigrist, R., Luhavaya, H., McKinnie, S. M. K., da Silva, A. F., Jurberg, I. D., Moore, B. S., & de Oliveira, L. G. (2020). Nonlinear biosynthetic assembly of alpiniamide by a hybrid cis/trans-AT PKS-NRPS. Acs Chemical Biology, 15(4), 1067-1077. doi: 10.1021/acschembio.0c00081
- Tang, X. Y., Kudo, Y., Baker, J. L., LaBonte, S., Jordan, P. A., McKinnie, S. M. K., ... Edlund, A. (2020). Cariogenic Streptococcus mutans produces tetramic acid strain-specific antibiotics that impair commensal colonization. Acs Infectious Diseases, 6(4), 563-571. doi: 10.1021/acsinfecdis.9b00365
- Fiore, M. F., de Lima, S. T., Carmichael, W. W., McKinnie, S. M. K., Chekan, J. R., & Moore, B. S. (2020). Guanitoxin, re-naming a cyanobacterial organophosphate toxin. Harmful Algae, 92(101737). doi: 10.1016/j.hal.2019.101737
- Zhang, J. J., Tang, X. Y., Huan, T., Ross, A. C., & Moore, B. S. (2020). Pass-back chain extension expands multimodular assembly line biosynthesis. Nature Chemical Biology, 16(1), 42-+. doi: 10.1038/s41589-019-0385-4
2019
- Chekan, J. R., Lee, G. Y., El Gamal, A., Purdy, T. N., Houk, K. N., & Moore, B. S. (2019). Bacterial tetrabromopyrrole debrominase shares a reductive dehalogenation strategy with human thyroid deiodinase. Biochemistry, 58(52), 5329-5338. doi: 10.1021/acs.biochem.9b00318
- Podell, S., Blanton, J. M., Neu, A., Agarwal, V., Biggs, J. S., Moore, B. S., & Allen, E. E. (2019). Pangenomic comparison of globally distributed Poribacteria associated with sponge hosts and marine particles. The ISME Journal. doi: 10.1038/s41396-018-0292-9
- Li, Z. R., Li, J., Cai, W. L., Lai, J. Y. H., McKinnie, S. M. K., Zhang, W. P., ... Qian, P. Y. (2019). Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nature Chemistry, 11(10), 880-889. doi: 10.1038/s41557-019-0317-7
- Zhang, J. J., Tang, X. Y., & Moore, B. S. (2019). Genetic platforms for heterologous expression of microbial natural products. Natural Product Reports, 36(9), 1313-1332. doi: 10.1039/c9np00025a
- Valiadi, M., de Rond, T., Amorim, A., Gittins, J. R., Gubili, C., Moore, B. S., ... Latz, M. I. (2019). Molecular and biochemical basis for the loss of bioluminescence in the dinoflagellate Noctiluca scintillans along the west coast of the USA. Limnology and Oceanography. doi: 10.1002/lno.11309
- Luhavaya, H., Sigrist, R., Chekan, J. R., McKinnie, S. M. K., & Moore, B. S. (2019). Biosynthesis of l-4-chlorokynurenine, an antidepressant prodrug and a non-proteinogenic amino acid found in lipopeptide antibiotics. Angewandte Chemie-International Edition, 58(25), 8394-8399. doi: 10.1002/anie.201901571
- Schorn, M. A., Jordan, P. A., Podell, S., Blanton, J. M., Agarwal, V., Biggs, J. S., ... Moore, B. S. (2019). Comparative genomics of cyanobacterial symbionts reveals distinct, specialized metabolism in tropical Dysideidae sponges. mBio, 10. doi: 10.1128/mBio.00821-19
- Chekan, J. R., McKinnie, S. M. K., Moore, M. L., Poplawski, S. G., Michael, T. P., & Moore, B. S. (2019). Scalable biosynthesis of the seaweed neurochemical, kainic acid. Angewandte Chemie-International Edition, 58(25), 8454-8457. doi: 10.1002/anie.201902910
- Walsh, C. T., & Moore, B. S. (2019). Enzymatic cascade reactions in biosynthesis. Angewandte Chemie-International Edition, 58(21), 6846-6879. doi: 10.1002/anie.201807844
- Bauman, K. D., Li, J., Murata, K., Mantovani, S. M., Dahesh, S., Nizet, V., ... Moore, B. S. (2019). Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry. Cell Chemical Biology, 26(5), 724-+. doi: 10.1016/j.chembiol.2019.02.004
- Busch, J., Agarwal, V., Schorn, M., Machado, H., Moore, B. S., Rouse, G. W., ... Jensen, P. R. (2019). Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas. Environmental Microbiology, 21(5), 1575-1585. doi: 10.1111/1462-2920.14532
- Rothe, M. L., Li, J., Garibay, E., Moore, B. S., & McKinnie, S. M. K. (2019). Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives. Organic & Biomolecular Chemistry, 17(13), 3416-3423. doi: 10.1039/c8ob03109f
- Thapa, H. R., Robbins, J. M., Moore, B. S., & Agarwal, V. (2019). Insights into thiotemplated pyrrole biosynthesis gained from the crystal structure of flavin-dependent oxidase in complex with carrier protein. Biochemistry, 58(7), 918-929. doi: 10.1021/acs.biochem.8b01177
- McAlpine, J. B., Chen, S. N., Kutateladze, A., MacMillan, J. B., Appendino, G., Barison, A., ... Pauli, G. F. (2019). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36(1), 35-107. doi: 10.1039/c7np00064b
- Zhang, J. J., Yamanaka, K., Tang, X. Y., & Moore, B. S. (2019). Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination. Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Pt A (pp. 87-110). San Diego: Elsevier Academic Press Inc. doi: 10.1016/bs.mie.2019.02.026
2018
- McKinnie, S. M. K., Miles, Z. D., Jordan, P. A., Awakawa, T., Pepper, H. P., Murray, L. A. M., ... Moore, B. S. (2018). Total enzyme syntheses of napyradiomycins A1 and B1. Journal of the American Chemical Society, 140(51), 17840-17845. doi: 10.1021/jacs.8b10134
- Schlawis, C., Kern, S., Kudo, Y., Grunenberg, J., Moore, B. S., & Schulz, S. (2018). Structural elucidation of trace components combining GC/MS, GC/IR, DFT-calculation and synthesis-salinilactones, unprecedented bicyclic lactones from Salinispora bacteria. Angewandte Chemie-International Edition, 57(45), 14921-14925. doi: 10.1002/anie.201807923
- Whalen, K. E., Kirby, C., Nicholson, R. M., O'Reilly, M., Moore, B. S., & Harvey, E. L. (2018). The chemical cue tetrabromopyrrole induces rapid cellular stress and mortality in phytoplankton. Scientific Reports, 8(15498). doi: 10.1038/s41598-018-33945-3
- Zhang, J. J., Moore, B. S., & Tang, X. Y. (2018). Engineering Salinispora tropica for heterologous expression of natural product biosynthetic gene clusters. Applied Microbiology and Biotechnology, 102(19), 8437-8446. doi: 10.1007/s00253-018-9283-z
- Brunson, J. K., McKinnie, S. M. K., Chekan, J. R., McCrow, J. P., Miles, Z. D., Bertrand, E. M., ... Moore, B. S. (2018). Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom. Science, 361(6409), 1356-+. doi: 10.1126/science.aau0382
- Murray, L. A. M., McKinnie, S. M. K., Pepper, H. P., Erni, R., Miles, Z. D., Cruickshank, M. C., ... George, J. H. (2018). Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products. Angewandte Chemie-International Edition, 57(34), 11009-11014. doi: 10.1002/anie.201804351
- Saleem-Batcha, R., Stull, F., Sanders, J. N., Moore, B. S., Palfey, B. A., Houk, K. N., & Teufel, R. (2018). Enzymatic control of dioxygen binding and functionalization of the flavin cofactor. Proceedings of the National Academy of Sciences of the United States of America, 115(19), 4909-4914. doi: 10.1073/pnas.1801189115
- Zheng, J., McKinnie, S. M. K., El Gama, A., Fengit, W., Dong, Y., Agarwal, V., ... Pessah, I. N. (2018). Organohalogens naturally biosynthesized in marine environments and produced as disinfection byproducts alter sarco/endoplasmic reticulum ca2+ dynamics. Environmental Science & Technology, 52(9), 5469-5478. doi: 10.1021/acs.est.8b00512
- Moore, B. S. (2018). Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis. Synlett, 29(4), 401-409. doi: 10.1055/s-0036-1590919
- Reynolds, K. A., Luhavaya, H., Li, J., Dahesh, S., Nizet, V., Yamanaka, K., & Moore, B. S. (2018). Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster. Journal of Antibiotics, 71(2), 333-338. doi: 10.1038/ja.2017.146
- Bruns, H., Crusemann, M., Letzel, A. C., Alanjary, M., McInerney, J. O., Jensen, P. R., ... Ziemert, N. (2018). Function-related replacement of bacterial siderophore pathways. Isme Journal, 12(2), 320-329. doi: 10.1038/ismej.2017.137
- McKinnie, S. M. K., Miles, Z. D., & Moore, B. S. (2018). Characterization and biochemical assays of Streptomyces vanadium-dependent chloroperoxidases. Marine Enzymes and Specialized Metabolism, Pt A (pp. 405-424). San Diego: Elsevier Academic Press Inc. doi: 10.1016/bs.mie.2018.02.016
- Chekan, J. R., & Moore, B. S. (2018). Preparation and characterization of tetrabromopyrrole debrominase from marine proteobacteria. Marine Enzymes and Specialized Metabolism, Pt B (pp. 253-265). San Diego: Elsevier Academic Press Inc. doi: 10.1016/bs.mie.2018.01.031
2017
- Amos, G. C. A., Awakawa, T., Tuttle, R. N., Letzel, A. C., Kim, M. C., Kudo, Y., ... Jensen, P. R. (2017). Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11121-E11130. doi: 10.1073/pnas.1714381115
- Miles, Z. D., Diethelm, S., Pepper, H. P., Huang, D. M., George, J. H., & Moore, B. S. (2017). A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis. Nature Chemistry, 9(12), 1235-1242. doi: 10.1038/nchem.2829
- Zhang, J. J., Tang, X. Y., Zhang, M., Nguyen, D., & Moore, B. S. (2017). Broad-host-range expression reveals native and host regulatory elements that influence heterologous antibiotic production in gram-negative bacteria. Mbio, 8(5). doi: 10.1128/mBio.01291-17
- Li, J., Tang, X. Y., Awakawa, T., & Moore, B. S. (2017). Enzymatic C-H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity. Angewandte Chemie-International Edition, 56(40), 12234-12239. doi: 10.1002/anie.201705239
- Letzel, A. C., Li, J., Amos, G. C. A., Millan-Aguinaga, N., Ginigini, J., Abdelmohsen, U. R., ... Jensen, P. R. (2017). Genomic insights into specialized metabolism in the marine actinomycete Salinispora. Environmental Microbiology, 19(9), 3660-3673. doi: 10.1111/1462-2920.13867
- Tang, X. Y., Li, J., & Moore, B. S. (2017). Minimization of the thiolactomycin biosynthetic pathway reveals that the cytochrome p450 enzyme tlmf is required for five-membered thiolactone ring formation. Chembiochem, 18(12), 1072-1076. doi: 10.1002/cbic.201700090
- Larson, C. B., Crusemann, M., & Moore, B. S. (2017). PCR-independent method of transformation-associated recombination reveals the cosmomycin biosynthetic gene cluster in an ocean streptomycete. Journal of Natural Products, 80(4), 1200-1204. doi: 10.1021/acs.jnatprod.6b01121
- Agarwal, V., Miles, Z. D., Winter, J. M., Eustaquio, A. S., El Gamal, A. A., & Moore, B. S. (2017). Enzymatic halogenation and dehalogenation reactions: Pervasive and mechanistically diverse. Chemical Reviews, 117(8), 5619-5674. doi: 10.1021/acs.chemrev.6b00571
- Crusemann, M., O'Neill, E. C., Larson, C. B., Melnik, A. V., Floros, D. J., da Silva, R. R., ... Moore, B. S. (2017). Prioritizing natural product diversity in a collection of 146 bacterial strains based on growth and extraction protocols. Journal of Natural Products, 80(3), 588-597. doi: 10.1021/acsjnatprod.6b00722
- Agarwal, V., Blanton, J. M., Podell, S., Taton, A., Schorn, M. A., Busch, J., ... Moore, B. S. (2017). Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nat Chem Biol, advance online publication. doi: 10.1038/nchembio.2330
- Patin, N. V., Schorn, M., Aguinaldo, K., Lincecum, T., Moore, B. S., & Jensen, P. R. (2017). Effects of actinomycete secondary metabolites on sediment microbial communities. Applied and Environmental Microbiology, 83(4). doi: 10.1128/aem.02676-16
- Nguyen, D. D., Melnik, A. V., Koyama, N., Lu, X. W., Schorn, M., Fang, J. S., ... Dorrestein, P. C. (2017). Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nature Microbiology, 2(1). doi: 10.1038/nmicrobiol.2016.197
2016
- Jordan, P. A., & Moore, B. S. (2016). Biosynthetic pathway connects cryptic ribosomally synthesized posttranslationally modified peptide genes with pyrroloquinoline alkaloids. Cell Chemical Biology, 23(12), 1504-1514. doi: 10.1016/j.chembiol.2016.10.009
- Schorn, M. A., Alanjary, M. M., Aguinaldo, K., Korobeynikov, A., Podell, S., Patin, N., ... Moore, B. S. (2016). Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. Microbiology-Sgm, 162(12), 2075-2086. doi: 10.1099/mic.0.000386
- Zhang, W. P., Lu, L., Lai, Q. L., Zhu, B. K., Li, Z. R., Xu, Y., ... Qian, P. Y. (2016). Family-wide structural characterization and genomic comparisons decode the diversity-oriented biosynthesis of thalassospiramides by marine proteobacteria. Journal of Biological Chemistry, 291(53), 27228-+. doi: 10.1074/jbc.M116.756858
- Groenhagen, U., De Oliveira, A. L. L., Fielding, E., Moore, B. S., & Schulz, S. (2016). Coupled biosynthesis of volatiles and salinosporamideA in Salinispora tropica. Chembiochem, 17(20), 1978-1985. doi: 10.1002/cbic.201600388
- Li, Z. R., Li, J., Gu, J. P., Lai, J. Y. H., Duggan, B. M., Zhang, W. P., ... Qian, P. Y. (2016). Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. Nature Chemical Biology, 12(10), 773-+. doi: 10.1038/nchembio.2157
- El Gamal, A., Agarwal, V., Rahman, I., & Moore, B. S. (2016). Enzymatic reductive dehalogenation controls the biosynthesis of marine bacterial pyrroles. Journal of the American Chemical Society, 138(40), 13167-13170. doi: 10.1021/jacs.6b08512
- Wang, M. X., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., ... Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34(8), 828-837. doi: 10.1038/nbt.3597
- Teufel, R., Agarwal, V., & Moore, B. S. (2016). Unusual flavoenzyme catalysis in marine bacteria. Current Opinion in Chemical Biology, 31, 31-39. doi: 10.1016/j.clopa.2016.01.001
- El Gamal, A., Agarwal, V., Diethelm, S., Rahman, I., Schorn, M. A., Sneed, J. M., ... Moore, B. S. (2016). Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proceedings of the National Academy of Sciences of the United States of America, 113(14), 3797-3802. doi: 10.1073/pnas.1519695113
- Harvey, E. L., Deering, R. W., Rowley, D. C., El Gamal, A., Schorn, M., Moore, B. S., ... Whalen, K. E. (2016). A bacterial quorum-sensing precursor induces mortality in the marine coccolithophore, Emiliania huxleyi. Frontiers in Microbiology, 7(59). doi: 10.3389/fmicb.2016.00059
- Cha, J. Y., Han, S., Hong, H. J., Cho, H., Kim, D., Kwon, Y., ... Kwak, Y. S. (2016). Microbial and biochemical basis of a Fusarium wilt-suppressive soil. Isme Journal, 10(1), 119-129. doi: 10.1038/ismej.2015.95
- Ray, L., Yamanaka, K., & Moore, B. S. (2016). A peptidyl-transesterifying type I thioesterase in salinamide biosynthesis. Angewandte Chemie-International Edition, 55(1), 364-367. doi: 10.1002/anie.201508576
2015
- Tang, X. Y., Li, J., Millan-Aguinaga, N., Zhang, J. J., O'Neill, E. C., Ugalde, J. A., ... Moore, B. S. (2015). Identification of thiotetronic acid antibiotic biosynthetic pathways by target-directed genome mining. Acs Chemical Biology, 10(12), 2841-2849. doi: 10.1021/acschembio.5b00658
- Kim, E., Moore, B. S., & Yoon, Y. J. (2015). Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nature Chemical Biology, 11(9), 649-659. doi: 10.1038/nchembio.1893
- Agarwal, V., Diethelm, S., Ray, L., Garg, N., Awakawa, T., Dorrestein, P. C., & Moore, B. S. (2015). Chemoenzymatic synthesis of acyl coenzyme a substrates enables in situ labeling of small molecules and proteins. Organic Letters, 17(18), 4452-4455. doi: 10.1021/acs.orglett.5b02113
- Awakawa, T., Crusemann, M., Munguia, J., Ziemert, N., Nizet, V., Fenical, W., & Moore, B. S. (2015). Salinipyrone and pacificanone are biosynthetic by-products of the rosamicin polyketide synthase. Chembiochem, 16(10), 1443-1447. doi: 10.1002/cbic.201500177
- Teufel, R., Stull, F., Meehan, M. J., Michaudel, Q., Dorrestein, P. C., Palfey, B., & Moore, B. S. (2015). Biochemical establishment and characterization of EncM's flavin-N5-oxide cofactor. Journal of the American Chemical Society, 137(25), 8078-8085. doi: 10.1021/jacs.5b03983
- Richter, T. K. S., Hughes, C. C., & Moore, B. S. (2015). Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway. Environmental Microbiology, 17(6), 2158-2171. doi: 10.1111/1462-2920.12669
- Ross, A. C., Gulland, L. E. S., Dorrestein, P. C., & Moore, B. S. (2015). Targeted capture and heterologous expression of the pseudoalteromonas alterochromide gene cluster in Escherichia coil represents a promising natural product exploratory platform. ACS Synthetic Biology, 4(4), 414-420. doi: 10.1021/sb500280q
- Duncan, K. R., Crusemann, M., Lechner, A., Sarkar, A., Li, J., Ziemert, N., ... Jensen, P. R. (2015). Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chemistry & Biology, 22(4), 460-471. doi: 10.1016/j.chembiol.2015.03.010
- Bonet, B., Teufel, R., Crusemann, M., Ziemert, N., & Moore, B. S. (2015). Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin. Journal of Natural Products, 78(3), 539-542. doi: 10.1021/np500664q
- Lu, L., Meehan, M. J., Gu, S., Chen, Z., Zhang, W., Zhang, G., ... Qian, P. (2015). Mechanism of action of thalassospiramides, a new class of calpain inhibitors. Scientific Reports, 5(8783). doi: 10.1038/srep08783
- Li, Y. X., Li, Z. R., Yamanaka, K., Xu, Y., Zhang, W. P., Vlamakis, H., ... Qian, P. Y. (2015). Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis. Scientific Reports, 5(9383). doi: 10.1038/srep09383
- Agarwal, V., Li, J., Rahman, I., Borgen, M., Aluwihare, L. I., Biggs, J. S., ... Moore, B. S. (2015). Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry. Environmental Science & Technology, 49(3), 1339-1346. doi: 10.1021/es505440j
2014
- Diethelm, S., Teufel, R., Kaysser, L., & Moore, B. S. (2014). A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins. Angewandte Chemie-International Edition, 53(41), 11023-11026. doi: 10.1002/anie.201405696
- Teufel, R., Kaysser, L., Villaume, M. T., Diethelm, S., Carbullido, M. K., Baran, P. S., & Moore, B. S. (2014). One-pot enzymatic synthesis of merochlorin A and B. Angewandte Chemie-International Edition, 53(41), 11019-11022. doi: 10.1002/anie.201405694
- Xu, M. M., Hillwig, M. L., Lane, A. L., Tiernan, M. S., Moore, B. S., & Peters, R. J. (2014). Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. Journal of Natural Products, 77(9), 2144-2147. doi: 10.1021/np500422d
- Agarwal, V., & Moore, B. S. (2014). Enzymatic synthesis of polybrominated dioxins from the marine environment. Acs Chemical Biology, 9(9), 1980-1984. doi: 10.1021/cb5004338
- Mohimani, H., Liu, W. T., Kersten, R. D., Moore, B. S., Dorrestein, P. C., & Pevzner, P. A. (2014). NRPquest: Coupling mass spectrometry and genome mining for nonribosomal peptide discovery. Journal of Natural Products, 77(8), 1902-1909. doi: 10.1021/np500370c
- Mohimani, H., Kersten, R. D., Liu, W. T., Wang, M. X., Purvine, S. O., Wu, S., ... Dorrestein, P. C. (2014). Automated genome mining of ribosomal peptide natural products. Acs Chemical Biology, 9(7), 1545-1551. doi: 10.1021/cb500199h
- Niewerth, D., Jansen, G., Riethoff, L. F. V., van Meerloo, J., Kale, A. J., Moore, B. S., ... Cloos, J. (2014). Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor Salinosporamide A (Marizomib). Molecular Pharmacology, 86(1), 12-19. doi: 10.1124/mol.114.092114
- Trivella, D. B. B., Pereira, A. R., Stein, M. L., Kasai, Y., Byrum, T., Valeriote, F. A., ... Moore, B. S. (2014). Enzyme inhibition by hydroamination: Design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chemistry & Biology, 21(6), 782-791. doi: 10.1016/j.chembiol.2014.04.010
- Agarwal, V., El Gamal, A. A., Yamanaka, K., Poth, D., Kersten, R. D., Schorn, M., ... Moore, B. S. (2014). Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. Nat Chem Biol, 10(8), 640-647. doi: 10.1038/nchembio.1564
- Jensen, P. R., Chavarria, K. L., Fenical, W., Moore, B. S., & Ziemert, N. (2014). Challenges and triumphs to genomics-based natural product discovery. Journal of Industrial Microbiology & Biotechnology, 41(2), 203-209. doi: 10.1007/s10295-013-1353-8
- Yamanaka, K., Reynolds, K. A., Kersten, R. D., Ryan, K. S., Gonzalez, D. J., Nizet, V., ... Moore, B. S. (2014). Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proceedings of the National Academy of Sciences of the United States of America, 111(5), 1957-1962. doi: 10.1073/pnas.1319584111
- Schorn, M., Zettler, J., Noel, J. P., Dorrestein, P. C., Moore, B. S., & Kaysser, L. (2014). Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. Acs Chemical Biology, 9(1), 301-309. doi: 10.1021/cb400699p
2013
- Mantovani, S. M., & Moore, B. S. (2013). Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine a. Journal of the American Chemical Society, 135(48), 18032-18035. doi: 10.1021/ja409520v
- Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., ... van der Donk, W. A. (2013). Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports, 30(1), 108-160. doi: 10.1039/c2np20085f
- Teufel, R., Miyanaga, A., Michaudel, Q., Stull, F., Louie, G., Noel, J. P., ... Moore, B. S. (2013). Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature, 503(7477), 552-+. doi: 10.1038/nature12643
- Kersten, R. D., Ziemert, N., Gonzalez, D. J., Duggan, B. M., Nizet, V., Dorrestein, P. C., & Moore, B. S. (2013). Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proceedings of the National Academy of Sciences of the United States of America, 110(47), E4407-E4416. doi: 10.1073/pnas.1315492110
- Horsman, G. P., Lechner, A., Ohnish, Y., Moore, B. S., & Shen, B. (2013). Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. Biochemistry, 52(31), 5217-5224. doi: 10.1021/bi400572a
- Lechner, A., Wilson, M. C., Ban, Y. H., Hwang, J. Y., Yoon, Y. J., & Moore, B. S. (2013). Designed biosynthesis of 36-methyl-fk506 by polyketide precursor pathway engineering. Acs Synthetic Biology, 2(7), 379-383. doi: 10.1021/sb3001062
- Nguyen, D. D., Wu, C. H., Moree, W. J., Lamsa, A., Medema, M. H., Zhao, X. L., ... Dorrestein, P. C. (2013). MS/MS networking guided analysis of molecule and gene cluster families. Proceedings of the National Academy of Sciences of the United States of America, 110(28), E2611-E2620. doi: 10.1073/pnas.1303471110
- Lipson, J. M., Thomsen, M., Moore, B. S., Clausen, R. P., La Clair, J. J., & Burkart, M. D. (2013). A Tandem Chemoenzymatic Methylation by S-Adenosyl-L-methionine. ChemBioChem, 14(8), 950-953. doi: 10.1002/cbic.201300221
- Kersten, R. D., Lane, A. L., Nett, M., Richter, T. K. S., Duggan, B. M., Dorrestein, P. C., & Moore, B. S. (2013). Bioactivity-Guided Genome Mining Reveals the Lomaiviticin Biosynthetic Gene Cluster in Salinispora tropica. ChemBioChem, 14(8), 955-962. doi: 10.1002/cbic.201300147
- Lane, A. L., Nam, S. J., Fukuda, T., Yamanaka, K., Kauffman, C. A., Jensen, P. R., ... Moore, B. S. (2013). Structures and Comparative Characterization of Biosynthetic Gene Clusters for Cyanosporasides, Enediyne-Derived Natural Products from Marine Actinomycetes. Journal of the American Chemical Society, 135(11), 4171-4174. doi: 10.1021/ja311065v
- Ross, A. C., Xu, Y., Lu, L., Kersten, R. D., Shao, Z. Z., Al-Suwailem, A. M., ... Moore, B. S. (2013). Biosynthetic Multitasking Facilitates Thalassospiramide Structural Diversity in Marine Bacteria. Journal of the American Chemical Society, 135(3), 1155-1162. doi: 10.1021/ja3119674
2012
- Kale, A. J., & Moore, B. S. (2012). Molecular Mechanisms of Acquired Proteasome Inhibitor Resistance. Journal of Medicinal Chemistry, 55(23), 10317-10327. doi: 10.1021/jm300434z
- Yang, J. Y., Phelan, V. V., Simkovsky, R., Watrous, J. D., Trial, R. M., Fleming, T. C., ... Dorrestein, P. C. (2012). Primer on Agar-Based Microbial Imaging Mass Spectrometry. Journal of Bacteriology, 194(22), 6023-6028. doi: 10.1128/jb.00823-12
- Richter, M., Busch, B., Ishida, K., Moore, B. S., & Hertweck, C. (2012). Pyran Formation by an Atypical CYP-Mediated Four-Electron Oxygenation-Cyclization Cascade in an Engineered Aureothin Pathway. Chembiochem, 13(15), 2196-2199. doi: 10.1002/Cbic.201200406
- Qian, Q., Schultz, A. W., Moore, B. S., & Tanner, M. E. (2012). Mechanistic Studies on CymD: A Tryptophan Reverse N-Prenyltransferase. Biochemistry, 51(39), 7733-7739. doi: 10.1021/bi3009054
- Roberts, A. A., Schultz, A. W., Kersten, R. D., Dorrestein, P. C., & Moore, B. S. (2012). Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. Fems Microbiology Letters, 335(2), 95-103. doi: 10.1111/j.1574-6968.2012.02641.x
- Yamanaka, K., Ryan, K. S., Gulder, T. A. M., Hughes, C. C., & Moore, B. S. (2012). Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis. Journal of the American Chemical Society, 134(30), 12434-12437. doi: 10.1021/ja305670f
- Kaysser, L., Bernhardt, P., Nam, S. J., Loesgen, S., Ruby, J. G., Skewes-Cox, P., ... Moore, B. S. (2012). Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. Journal of the American Chemical Society, 134(29), 11988-11991. doi: 10.1021/ja305665f
- Watrous, J., Roach, P., Alexandrov, T., Heath, B. S., Yang, J. Y., Kersten, R. D., ... Dorrestein, P. C. (2012). Mass spectral molecular networking of living microbial colonies. Proceedings of the National Academy of Sciences of the United States of America, 109(26), E1743-E1752. doi: 10.1073/pnas.1203689109
- Xu, Y., Kersten, R. D., Nam, S. J., Lu, L., Al-Suwailem, A. M., Zheng, H. J., ... Qian, P. Y. (2012). Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. Journal of the American Chemical Society, 134(20), 8625-8632. doi: 10.1021/ja301735a
- Chen, Z. H., Wang, B. L., Kale, A. J., Moore, B. S., Wang, R. W., & Qing, F. L. (2012). Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A. Journal of Fluorine Chemistry, 136, 12-19. doi: 10.1016/j.jfluchem.2012.01.003
- Gonzalez, D. J., Okumura, C. Y., Hollands, A., Kersten, R., Akong-Moore, K., Pence, M. A., ... Nizet, V. (2012). Novel Phenol-soluble Modulin Derivatives in Community-associated Methicillin-resistant Staphylococcus aureus Identified through Imaging Mass Spectrometry. Journal of Biological Chemistry, 287(17), 13889-13898. doi: 10.1074/jbc.M112.349860
- Pereira, A. R., Kale, A. J., Fenley, A. T., Byrum, T., Debonsi, H. M., Gilson, M. K., ... Gerwick, W. H. (2012). The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. Chembiochem, 13(6), 810-817. doi: 10.1002/Cbic.201200007
- Jones, A. C., Ottilie, S., Eustaquio, A. S., Edwards, D. J., Gerwick, L., Moore, B. S., & Gerwick, W. H. (2012). Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS Journal, 279(7), 1243-1251. doi: 10.1111/j.1742-4658.2012.08517.x
- Gerwick, W. H., & Moore, B. S. (2012). Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chemistry & Biology, 19(1), 85-98. doi: 10.1016/j.chembiol.2011.12.014
- Wilson, M. C., & Moore, B. S. (2012). Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. Natural Product Reports, 29(1), 72-86. doi: 10.1039/c1np00082a
2011
- Lechner, A., Eustaquio, A. S., Gulder, T. A. M., Hafner, M., & Moore, B. S. (2011). Selective Overproduction of the Proteasome Inhibitor Salinosporamide A via Precursor Pathway Regulation. Chemistry & Biology, 18(12), 1527-1536. doi: 10.1016/j.chembiol.2011.10.014
- Kale, A. J., McGlinchey, R. P., Lechner, A., & Moore, B. S. (2011). Bacterial Self-Resistance to the Natural Proteasome Inhibitor Salinosporamide A. Acs Chemical Biology, 6(11), 1257-1264. doi: 10.1021/cb2002544
- Kersten, R. D., Yang, Y. L., Xu, Y. Q., Cimermancic, P., Nam, S. J., Fenical, W., ... Dorrestein, P. C. (2011). A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nature Chemical Biology, 7(11), 794-802. doi: 10.1038/nchembio.684
- Liu, W. T., Kersten, R. D., Yang, Y. L., Moore, B. S., & Dorrestein, P. C. (2011). Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin in Streptomyces roseosporus. Journal of the American Chemical Society, 133(45), 18010-18013. doi: 10.1021/ja2040877
- Kalaitzis, J. A., Cheng, Q., Meluzzi, D., Xiang, L. K., Izumikawa, M., Dorrestein, P. C., & Moore, B. S. (2011). Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorganic & Medicinal Chemistry, 19(22), 6633-6638. doi: 10.1016/j.bmc.2011.04.024
- Miyanaga, A., Janso, J. E., McDonald, L., He, M., Liu, H. B., Barbieri, L., ... Moore, B. S. (2011). Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora Bacteria. Journal of the American Chemical Society, 133(34), 13311-13313. doi: 10.1021/ja205655w
- Udwary, D. W., Gontang, E. A., Jones, A. C., Jones, C. S., Schultz, A. W., Winter, J. M., ... Moore, B. S. (2011). Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses. Applied and Environmental Microbiology, 77(11), 3617-3625. doi: 10.1128/aem.00038-11
- Bernhardt, P., Okino, T., Winter, J. M., Miyanaga, A., & Moore, B. S. (2011). A Stereoselective Vanadium-Dependent Chloroperoxidase in Bacterial Antibiotic Biosynthesis. Journal of the American Chemical Society, 133(12), 4268-4270. doi: 10.1021/ja201088k
- Wilson, M. C., Nam, S. J., Gulder, T. A. M., Kauffman, C. A., Jensen, P. R., Fenical, W., & Moore, B. S. (2011). Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. Journal of the American Chemical Society, 133(6), 1971-1977. doi: 10.1021/ja109226s
- Mo, S., Kim, D. H., Lee, J. H., Park, J. W., Basnet, D. B., Ban, Y. H., ... Yoon, Y. J. (2011). Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues. Journal of the American Chemical Society, 133(4), 976-985. doi: 10.1021/ja108399b
- Eustaquio, A. S., Nam, S. J., Penn, K., Lechner, A., Wilson, M. C., Fenical, W., ... Moore, B. S. (2011). The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem, 12(1), 61-64. doi: 10.1002/cbic.201000564
- Lane, A. L., & Moore, B. S. (2011). A sea of biosynthesis: marine natural products meet the molecular age. Natural Product Reports, 28(2), 411-428. doi: 10.1039/c0np90032j
- Yang, Y. L., Xu, Y. Q., Kersten, R. D., Liu, W. T., Meehan, M. J., Moore, B. S., ... Dorrestein, P. C. (2011). Connecting Chemotypes and Phenotypes of Cultured Marine Microbial Assemblages by Imaging Mass Spectrometry. Angewandte Chemie-International Edition, 50(26), 5839-5842. doi: 10.1002/anie.201101225
2010
- Kale, A. J., McGlinchey, R. P., & Moore, B. S. (2010). Characterization of 5-Chloro-5-Deoxy-D-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis SUBSTRATE AND REACTION PROFILING. Journal of Biological Chemistry, 285(44), 33710-33717. doi: 10.1074/jbc.M110.153833
- Mahlstedt, S., Fielding, E. N., Moore, B. S., & Walsh, C. T. (2010). Prephenate Decarboxylases: A New Prephenate-Utilizing Enzyme Family That Performs Nonaromatizing Decarboxylation en Route to Diverse Secondary Metabolites. Biochemistry, 49(42), 9021-9023. doi: 10.1021/bi101457h
- Wilson, M. C., Gulder, T. A. M., Mahmud, T., & Moore, B. S. (2010). Shared Biosynthesis of the Saliniketals and Rifamycins in Salinispora arenicola is Controlled by the sare1259-Encoded Cytochrome P450. Journal of the American Chemical Society, 132(36), 12757-12765. doi: 10.1021/ja105891a
- Werneburg, M., Busch, B., He, J., Richter, M. E. A., Xiang, L. K., Moore, B. S., ... Hertweck, C. (2010). Exploiting Enzymatic Promiscuity to Engineer a Focused Library of Highly Selective Antifungal and Antiproliferative Aureothin Analogues. Journal of the American Chemical Society, 132(30), 10407-10413. doi: 10.1021/ja102751h
- Schultz, A. W., Lewis, C. A., Luzung, M. R., Baran, P. S., & Moore, B. S. (2010). Functional Characterization of the Cyclomarin/Cyclomarazine Prenyltransferase CymD Directs the Biosynthesis of Unnatural Cyclic Peptides. Journal of Natural Products, 73(3), 373-377. doi: 10.1021/np9006876
- Eustaquio, A. S., O'Hagan, D., & Moore, B. S. (2010). Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide. Journal of Natural Products, 73(3), 378-382. doi: 10.1021/np900719u
- Roberts, A. A., Ryan, K. S., Moore, B. S., & Gulder, T. A. M. (2010). Total (Bio)Synthesis: Strategies of Nature and of Chemists. Natural Products Via Enzymatic Reactions (pp. 149-203). Berlin: Springer-Verlag Berlin. doi: 10.1007/128_2010_79
- Gulder, T. A. M., & Moore, B. S. (2010). Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics. Angewandte Chemie-International Edition, 49(49), 9346-9367. doi: 10.1002/anie.201000728
2009
- Deng, H., McMahon, S. A., Eustaquio, A. S., Moore, B. S., Naismith, J. H., & O'Hagan, D. (2009). Mechanistic Insights into Water Activation in SAM Hydroxide Adenosyltransferase (duf-62). Chembiochem, 10(15), 2455-2459. doi: 10.1002/cbic.200900369
- Nett, M., Guider, T. A. M., Kale, A. J., Hughes, C. C., & Moore, B. S. (2009). Function-Oriented Biosynthesis of beta-Lactone Proteasome Inhibitors in Salinispora tropica. Journal of Medicinal Chemistry, 52(19), 6163-6167. doi: 10.1021/Jm901098m
- Penn, K., Jenkins, C., Nett, M., Udwary, D. W., Gontang, E. A., McGlinchey, R. P., ... Jensen, P. R. (2009). Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. Isme Journal, 3(10), 1193-1203. doi: 10.1038/ismej.2009.58
- Liu, Y., Hazzard, C., Eustaquio, A. S., Reynolds, K. A., & Moore, B. S. (2009). Biosynthesis of Salinosporamides from alpha,beta-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity. Journal of the American Chemical Society, 131(30), 10376-+. doi: 10.1021/ja9042824
- Winter, J. M., & Moore, B. S. (2009). Exploring the Chemistry and Biology of Vanadium-dependent Haloperoxidases. Journal of Biological Chemistry, 284(28), 18577-18581. doi: 10.1074/jbc.R109.001602
- Eustaquio, A. S., McGlinchey, R. P., Liu, Y., Hazzard, C., Beer, L. L., Florova, G., ... Moore, B. S. (2009). Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proceedings of the National Academy of Sciences of the United States of America, 106(30), 12295-12300. doi: 10.1073/pnas.0901237106
- Liu, W. T., Ng, J., Meluzzi, D., Bandeira, N., Gutierrez, M., Simmons, T. L., ... Dorrestein, P. C. (2009). Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Analytical Chemistry, 81(11), 4200-4209. doi: 10.1021/ac900114t
- Nett, M., & Moore, B. S. (2009). Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica. Pure and Applied Chemistry, 81(6), 1075-1084. doi: 10.1351/pac-con-08-08-08
- Gulder, T. A. M., & Moore, B. S. (2009). Chasing the treasures of the sea - bacterial marine natural products. Current Opinion in Microbiology, 12(3), 252-260. doi: 10.1016/j.mib.2009.05.002
- Kalaitzis, J. A., Cheng, Q., Thomas, P. M., Kelleher, N. L., & Moore, B. S. (2009). In Vitro Biosynthesis of Unnatural Enterocin and Wailupemycin Polyketides. Journal of Natural Products, 72(3), 469-472. doi: 10.1021/np800598t
- Nett, M., Ikeda, H., & Moore, B. S. (2009). Genomic basis for natural product biosynthetic diversity in the actinomycetes. Natural Product Reports, 26(11), 1362-1384. doi: 10.1039/b817069j
- Winter, J. M., Jansma, A. L., Handel, T. M., & Moore, B. S. (2009). Formation of the Pyridazine Natural Product Azamerone by Biosynthetic Rearrangement of an Aryl Diazoketone. Angewandte Chemie-International Edition, 48(4), 767-770. doi: 10.1002/anie.200805140
2008
- Eustaquio, A. S., Harle, J., Noel, J. P., & Moore, B. S. (2008). S-Adenosyl-L-Methionine Hydrolase (Adenosine-Forming), a Conserved Bacterial and Archeal Protein Related to SAM-Dependent Halogenases. Chembiochem, 9(14), 2215-2219. doi: 10.1002/cbic.200800341
- Worthington, A. S., Hur, G. H., Meier, J. L., Cheng, Q., Moore, B. S., & Burkart, M. D. (2008). Probing the compatibility of type II ketosynthase-carrier protein partners. Chembiochem, 9(13), 2096-2103. doi: 10.1002/cbic.200800198
- Moore, B. S., Eustaquio, A. S., & McGlinchey, R. P. (2008). Advances in and applications of proteasome inhibitors. Current Opinion in Chemical Biology, 12(4), 434-440. doi: 10.1016/j.cbpa.2008.06.033
- McGlinchey, R. P., Nett, M., Eustaquio, A. S., Asolkar, R. N., Fenical, W., & Moore, B. S. (2008). Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. Journal of the American Chemical Society, 130(25), 7822-+. doi: 10.1021/ja8029398
- Schultz, A. W., Oh, D. C., Carney, J. R., Williamson, R. T., Udwary, D. W., Jensen, P. R., ... Moore, B. S. (2008). Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. Journal of the American Chemical Society, 130(13), 4507-4516. doi: 10.1021/ja711188x
- McGlinchey, R. P., Nett, M., & Moore, B. S. (2008). Unraveling the biosynthesis of the sporolide cyclohexenone building block. Journal of the American Chemical Society, 130(8), 2406-2407. doi: 10.1021/ja710488m
- Eustaquio, A. S., Pojer, F., Noe, J. P., & Moore, B. S. (2008). Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nature Chemical Biology, 4(1), 69-74. doi: 10.1038/nchembio.2007.56
- Moore, B. S. (2008). Extending the Biosynthetic Repertoire in Ribosomal Peptide Assembly. Angewandte Chemie-International Edition, 47(49), 9386-9388. doi: 10.1002/anie.200803868
- Eustaquio, A. S., & Moore, B. S. (2008). Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angewandte Chemie-International Edition, 47(21), 3936-3938. doi: 10.1002/anie.200800177
- Udwary, D. W., Kalaitzis, J. A., & Moore, B. S. (2008). Emerging marine biotechnologies – Cloning of marine biosynthetic gene clusters. Oceans and human health (pp. 507-524). Amsterdam ; Boston: Elsevier.
2007
- Cheng, Q., Xiang, L., Izumikawa, M., Meluzzi, D., & Moore, B. S. (2007). Enzymatic total synthesis of enterocin polyketides. Nature Chemical Biology, 3(9), 557-558. doi: 10.1038/nchembio.2007.22
- Udwary, D. W., Zeigler, L., Asolkar, R. N., Singan, V., Lapidus, A., Fenical, W., ... Moore, B. S. (2007). Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proceedings of the National Academy of Sciences of the United States of America, 104(25), 10376-10381. doi: 10.1073/pnas.0700962104
- Winter, J. M., Moffitt, M. C., Zazopoulos, E., McAlpine, J. B., Dorrestein, P. C., & Moore, B. S. (2007). Molecular basis for chloronium-mediated meroterpene cyclization - Cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. Journal of Biological Chemistry, 282(22), 16362-16368. doi: 10.1074/jbc.M611046200
- Beer, L. L., & Moore, B. S. (2007). Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Organic Letters, 9(5), 845-848. doi: 10.1021/ol063102o
- Moffitt, M. C., Louie, G. V., Bowman, M. E., Pence, J., Noel, J. P., & Moore, B. S. (2007). Discovery of two cyanobacterial phenylalanine ammonia lyases: Kinetic and structural characterization. Biochemistry, 46(4), 1004-1012. doi: 10.1021/bi061774g
2006
- Louie, G. V., Bowman, M. E., Moffitt, M. C., Baiga, T. J., Moore, B. S., & Noel, J. P. (2006). Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chemistry & Biology, 13(12), 1327-1338. doi: 10.1016/j.chembiol.2006.11.011
- Song, L. J., Barona-Gomez, F., Corre, C., Xiang, L. K., Udwary, D. W., Austin, M. B., ... Challis, G. L. (2006). Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. Journal of the American Chemical Society, 128(46), 14754-14755. doi: 10.1021/ja065247w
- Austin, M. B., Saito, T., Bowman, M. E., Haydock, S., Kato, A., Moore, B. S., ... Noel, J. P. (2006). Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid - type III polyketide synthase. Nature Chemical Biology, 2(9), 494-502. doi: 10.1038/nchembio811
- Izumikawa, W., Cheng, Q., & Moore, B. S. (2006). Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism. Journal of the American Chemical Society, 128(5), 1428-1429. doi: 10.1021/ja0559707
- Moore, B. S. (2006). Biosynthesis of marine natural products: macroorganisms (Part B). Natural Product Reports, 23(4), 615-629. doi: 10.1039/b508781n
- Hicks, L. M., Moffitt, M. C., Beer, L. L., Moore, B. S., & Kelleher, N. L. (2006). Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. Acs Chemical Biology, 1(2), 93-102. doi: 10.1021/cb500007v
2005
- Xiang, L. K., & Moore, B. S. (2005). Biochemical characterization of a prokaryotic phenylalanine ammonia lyase. Journal of Bacteriology, 187(12), 4286-4289. doi: 10.1128/jb.187.12.4286-4289.2005
- Zhao, B., Guengerich, F. P., Bellamine, A., Lamb, D. C., Izumikawa, M., Lei, L., ... Waterman, M. R. (2005). Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. Journal of Biological Chemistry, 280(12), 11599-11607. doi: 10.1074/jbc.M410933200
- Moore, B. S., Kalaitzis, J. A., & Xiang, L. K. (2005). Exploiting marine actinomycete biosynthetic pathways for drug discovery. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 87(1), 49-57. doi: 10.1007/s10482-004-6541-0
- Moore, B. S. (2005). Biosynthesis of marine natural products: microorganisms (Part A). Natural Product Reports, 22(5), 580-593. doi: 10.1039/b404737k
2004
- Xiang, L., Kalaitzis, J. A., & Moore, B. S. (2004). EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions. Proceedings of the National Academy of Sciences of the United States of America, 101(44), 15609-15614. doi: 10.1073/pnas.0405508101
- Austin, M. B., Izumikawa, M., Bowman, M. E., Udwary, D. W., Ferrer, J. L., Moore, B. S., & Noel, J. P. (2004). Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. Journal of Biological Chemistry, 279(43), 45162-45174. doi: 10.1074/jbc.M406567200
- Garcia-Bernardo, J., Xiang, L. K., Hong, H., Moore, B. S., & Leadlay, P. F. (2004). Engineered biosynthesis of phenyl-substituted polyketides. Chembiochem, 5(8), 1129-1131. doi: 10.1002/cbic.200400007
- Kalaitzis, J. A., & Moore, B. S. (2004). Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase. Journal of Natural Products, 67(8), 1419-1422. doi: 10.1021/np0499564
- Hertweck, C., Xiang, L. K., Kalaitzis, J. A., Cheng, Q., Palzer, M., & Moore, B. S. (2004). Context-dependent behavior of the enterocin iterative polyketide synthase: A new model for ketoreduction. Chemistry & Biology, 11(4), 461-468. doi: 10.1016/j.chembiol.2004.03.018
- Becker, J. E., Moore, R. E., & Moore, B. S. (2004). Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization. Gene, 325, 35-42. doi: 10.1016/j.gene.2003.09.034
2003
- Kalaitzis, J. A., Hamano, Y., Nilsen, G., & Moore, B. S. (2003). Biosynthesis and structural revision of neomarinone. Organic Letters, 5(23), 4449-4452. doi: 10.1021/ol035748b
- Kalaitzis, J. A., Izumikawa, M., Xiang, L. K., Hertweck, C., & Moore, B. S. (2003). Mutasynthesis of enterocin and wailupemycin analogues. Journal of the American Chemical Society, 125(31), 9290-9291. doi: 10.1021/ja035973o
- Izumikawa, M., Shipley, P. R., Hopke, J. N., O'Hare, T., Xiang, L. K., Noel, J. P., & Moore, B. S. (2003). Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). Journal of Industrial Microbiology & Biotechnology, 30(8), 510-515. doi: 10.1007/s10295-003-0075-8
- Hoffmann, D., Hevel, J. M., Moore, R. E., & Moore, B. S. (2003). Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp GSV224. Gene, 311, 171-180. doi: 10.1016/s0378-1119(03)00587-0
- Xiang, L. K., & Moore, B. S. (2003). Characterization of benzoyl coenzyme a biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus". Journal of Bacteriology, 185(2), 399-404. doi: 10.1128/jb.185.2.399-404.2003
2002
- Moore, B. S., Hertweck, C., Hopke, J. N., Izumikawa, M., Kalaitzis, J. A., Nilsen, G., ... Noel, J. P. (2002). Plant-like biosynthetic pathways in bacteria: From benzoic acid to chalcone. Journal of Natural Products, 65(12), 1956-1962. doi: 10.1021/np020230m
- Hentschel, U., Hopke, J., Horn, M., Friedrich, A. B., Wagner, M., Hacker, J., & Moore, B. S. (2002). Molecular evidence for a uniform microbial community in sponges from different oceans. Applied and Environmental Microbiology, 68(9), 4431-4440. doi: 10.1128/aem.68.9.4431-4440.2002
- Xiang, L. K., & Moore, B. S. (2002). Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene. Journal of Biological Chemistry, 277(36), 32505-32509. doi: 10.1074/jbc.M204171200
- Xiang, L. K., Kalaitzis, J. A., Nilsen, G., Chen, L., & Moore, B. S. (2002). Mutational analysis of the enterocin Favorskii biosynthetic rearrangement. Organic Letters, 4(6), 957-960. doi: 10.1021/ol0255155
- Moore, B. S. (2002). The Interface of Natural Product Chemistry and Biology. Marine biotechnology in the twenty-first century : problems, promise, and products (pp. 61-64). Washington, DC: National Academy Press.
- Moore, B. S., & Hertweck, C. (2002). Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Natural Product Reports, 19(1), 70-99. doi: 10.1039/b003939j
2001
- Hertweck, C., Jarvis, A. P., Xiang, L. K., Moore, B. S., & Oldham, N. J. (2001). A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation. Chembiochem, 2(10), 784-+. doi: 10.1002/1439-7633(20011001)2:10<784::aid-cbic784>3.0.co;2-k
- Moore, B. S., & Hopke, J. N. (2001). Discovery of a new bacterial polyketide biosynthetic pathway. Chembiochem, 2(1), 35-38. doi: 10.1002/1439-7633(20010105)2:1<35::aid-cbic35>3.0.co;2-1
2000
- Moore, B. S., & Piel, J. (2000). Engineering biodiversity with type II polyketide synthase genes. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 78(3-4), 391-398.
- Piel, J., Hertweck, C., Shipley, P. R., Hunt, D. M., Newman, M. S., & Moore, B. S. (2000). Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. Chemistry & Biology, 7(12), 943-955. doi: 10.1016/s1074-5521(00)00044-2
- Hertweck, C., & Moore, B. S. (2000). A plant-like biosynthesis of benzoyl-CoA in the marine bacterium 'Streptomyces maritimus'. Tetrahedron, 56(46), 9115-9120. doi: 10.1016/s0040-4020(00)00765-1
- Piel, J., Hoang, K., & Moore, B. S. (2000). Natural metabolic diversity encoded by the enterocin biosynthesis gene cluster. Journal of the American Chemical Society, 122(22), 5415-5416. doi: 10.1021/ja000445n
1999
- Yu, T. W., Shen, Y. M., Doi-Katayama, Y., Tang, L., Park, C., Moore, B. S., ... Floss, H. G. (1999). Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. Proceedings of the National Academy of Sciences of the United States of America, 96(16), 9051-9056. doi: 10.1073/pnas.96.16.9051
- Shen, Y. M., Yoon, P., Yu, T. W., Floss, H. G., Hopwood, D., & Moore, B. S. (1999). Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes. Proceedings of the National Academy of Sciences of the United States of America, 96(7), 3622-3627. doi: 10.1073/pnas.96.7.3622
- Moore, B. S., Trischman, J. A., Seng, D., Kho, D., Jensen, P. R., & Fenical, W. (1999). Salinamides, antiinflammatory depsipeptides from a marine streptomycete. Journal of Organic Chemistry, 64(4), 1145-1150. doi: 10.1021/jo9814391
- Moore, B. S., & Floss, H. G. (1999). Biosynthesis of Cyclic Fatty Acids Containing Cyclopropyl-, Cyclopentyl-, Cyclohexyl-, and Cycloheptyl-rings. Comprehensive Natural Products Chemistry (pp. 61-82). Oxford: Pergamon. doi: 10.1016/B978-0-08-091283-7.00002-3
- Doi-Katayama, Y., Tang, L., Park, C., Yu, T. W., Moore, B., Floss, H. G., & Hutchinson, C. R. (1999). Biosynthesis of the Ansamycin Antibiotic Rifamycin: Polyketide Synthase Processes Multiple Polyketide Chains Simultaneously. Symposium on the Chemistry of Natural Products
- Moore, B. S. (1999). Biosynthesis of marine natural products: microorganisms and macroalgae. Natural Product Reports, 16(6), 653-674. doi: 10.1039/a805873c
1998
- Yu, T. W., Shen, Y. M., McDaniel, R., Floss, H. G., Khosla, C., Hopwood, D. A., & Moore, B. S. (1998). Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases. Journal of the American Chemical Society, 120(31), 7749-7759. doi: 10.1021/ja9803658
- Moore, B. S., & Seng, D. (1998). Biosynthesis of the bicyclic depsipeptide salinamide A in Streptomyces sp. CNB-091: Origin of the carbons. Tetrahedron Letters, 39(23), 3915-3918. doi: 10.1016/s0040-4039(98)00726-6
- Moore, B. S. (1998). "Biosynthetic Studies on the Salinamides, Depsipeptides from a Marine Streptomyces". New Developments in Marine Biotechnology (pp. xvi, 343 p.). New York: Plenum Press.
1997
- Moore, B. S., Walker, K., Tornus, I., Handa, S., Poralla, K., & Floss, H. G. (1997). Biosynthetic studies of omega-cycloheptyl fatty acids in Alicyclobacillus cycloheptanicus. Formation of cycloheptanecarboxylic acid from phenylacetic acid. Journal of Organic Chemistry, 62(7), 2173-2185. doi: 10.1021/Jo962402o
1995
- Moore, B. S., Eisenberg, R., Weber, C., Bridges, A., Nanz, D., & Robinson, J. A. (1995). On the Stereospecificity of the Coenzyme B-12-Dependent Isobutyryl-Coa Mutase Reaction. Journal of the American Chemical Society, 117(45), 11285-11291. doi: 10.1021/ja00150a028
- Skubatz, H., Svee, E. R., Moore, B. S., Howald, W. N., Tang, W., & Meeuse, B. (1995). Oleic Acid and Its Positional Isomer, cis-Vaccinic Acid, in the Appendix of Sauromatum guttatum during Anthesis. Plant Physiol, 107(4), 1433-1438.
- Moore, B. S., Floss, H. G., & Poralla, K. (1995). 3 New Omega-Cycloheptyl Fatty-Acids from Alicyclobacillus-Cycloheptanicus and Their Biosynthetic Interrelationships. Journal of Natural Products-Lloydia, 58(4), 590-593. doi: 10.1021/np50118a019
- Floss, H. G., Kim, C., & Moore, B. (1995). New Variants of the Shikimate Pathway in the Biosynthesis of Antibiotics and Other Microbial Metabolites. Sekundärmetabolismus Bei Mikroorganismen: Beiträge Zur Forschung. Tübingen, Germany: Attempto-Verlag.
1994
- Wallace, K. K., Reynolds, K. A., Koch, K., McArthur, H. A. I., Brown, M. S., Wax, R. G., & Moore, B. S. (1994). Biosynthetic-Studies of Ascomycin (Fk520) - Formation of the (1r,3r,4r)-3,4-Dihydroxycyclohexanecarboxylic Acid-Derived Moiety. Journal of the American Chemical Society, 116(25), 11600-11601. doi: 10.1021/ja00104a063
- Moore, B. S., & Floss, H. G. (1994). Biosynthetic-Studies on the Origin of the Cyclohexanecarboxylic Acid Moiety of Ansatrienin-a and Omega-Cyclohexyl Fatty-Acids. Journal of Natural Products, 57(3), 382-386. doi: 10.1021/np50105a008
1993
- Pratum, T. K., & Moore, B. S. (1993). Inverse Detection of C-13 Multiple-Quantum Coherence for Biosynthetic-Studies. Journal of Magnetic Resonance Series B, 102(1), 91-97. doi: 10.1006/jmrb.1993.1067
- Moore, R. E., Ohtani, I., Moore, B. S., Dekoning, C. B., Yoshida, W. Y., Runnegar, M. T. C., & Carmichael, W. W. (1993). Cyanobacterial Toxins. Gazzetta Chimica Italiana, 123(6), 329-336.
- Moore, B. S., Cho, H. J., Casati, R., Kennedy, E., Reynolds, K. A., Mocek, U., ... Floss, H. G. (1993). Biosynthetic-Studies on Ansatrienin-a - Formation of the Cyclohexanecarboxylic Acid Moiety. Journal of the American Chemical Society, 115(12), 5254-5266. doi: 10.1021/ja00065a042
- Moore, B. S., Poralla, K., & Floss, H. G. (1993). Biosynthesis of the Cyclohexanecarboxylic Acid Starter Unit of Omega-Cyclohexyl Fatty-Acids in Alicyclobacillus-Acidocaldarius. Journal of the American Chemical Society, 115(12), 5267-5274. doi: 10.1021/ja00065a043
1992
- Moore, B. S., Ohtani, I., Dekoning, C. B., Moore, R. E., & Carmichael, W. W. (1992). Biosynthesis of Anatoxin-a(S) - Origin of the Carbons. Tetrahedron Letters, 33(44), 6595-6598. doi: 10.1016/S0040-4039(00)60994-2
- Moore, B. S., Chen, J. L., Patterson, G. M. L., & Moore, R. E. (1992). Structures of Cylindrocyclophanes a-F. Tetrahedron, 48(15), 3001-3006. doi: 10.1016/s0040-4020(01)92244-6
- Floss, H. G., Cho, H., Casati, R., Reynolds, K. A., Kennedy, E., Moore, B. S., ... Poralla, K. (1992). Diversions of the Shikimate Pathway — The Biosynthesis of Cyclohexanecarboxylic Acid. Secondary-Metabolite Biosynthesis and Metabolism (pp. 77-88). : Springer US. doi: 10.1007/978-1-4615-3012-1_6
1991
- Moore, R. E., Chen, J. L., Moore, B. S., Patterson, G. M. L., & Carmichael, W. W. (1991). Biosynthesis of Microcystin-Lr - Origin of the Carbons in the Adda and Masp Units. Journal of the American Chemical Society, 113(13), 5083-5084. doi: 10.1021/Ja00013a066
1990
- Moore, B. S., Chen, J. L., Patterson, G. M. L., Moore, R. E., Brinen, L. S., Kato, Y., & Clardy, J. (1990). 7.7 Paracyclophanes from Blue-Green-Algae. Journal of the American Chemical Society, 112(10), 4061-4063. doi: 10.1021/ja00166a066
1989
- Moore, R. E., Banarjee, S., Bornemann, V., Caplan, F. R., Chen, J. L., Corley, D. G., ... Williams, D. E. (1989). Novel Cytotoxins and Fungicides from Blue-Green-Algae and Marine Animals Possessing Algal Symbionts. Pure and Applied Chemistry, 61(3), 521-524. doi: 10.1351/pac198961030521