Publications

225 publications

2021

Medema, M. H., de Rond, T., & Moore, B. S. (2021). Mining genomes to illuminate the specialized chemistry of life. Nature Reviews Genetics, 19. doi: 10.1038/s41576-021-00363-7
de Rond, T., Asay, J. E., & Moore, B. S. (2021). Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase. Nature Chemical Biology, 12. doi: 10.1038/s41589-021-00808-4
Adak, S., & Moore, B. S. (2021). Cryptic halogenation reactions in natural product biosynthesis. Natural Product Reports. doi: 10.1039/d1np00010a
Purdy, T. N., Kim, M. C., Cullum, R., Fenical, W., & Moore, B. S. (2021). Discovery and biosynthesis of tetrachlorizine reveals enzymatic benzylic dehydrogenation via an ortho-quinone methide. Journal of the American Chemical Society, 143(10), 3682-3686. doi: 10.1021/jacs.0c12415
Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., ... van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. doi: 10.1038/s41589-020-00724-z

2020

Chekan, J. R., Fallon, T. R., & Moore, B. S. (2020). Biosynthesis of marine toxins. Current Opinion in Chemical Biology, 59, 119-129. doi: 10.1016/j.cbpa.2020.06.009
Kudo, Y., Awakawa, T., Du, Y. L., Jordan, P. A., Creamer, K. E., Jensen, P. R., ... Moore, B. S. (2020). Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products. Acs Chemical Biology, 15(12), 3253-3261. doi: 10.1021/acschembio.0c00824
Murray, L. A. M., McKinnie, S. M. K., Moore, B. S., & George, J. H. (2020). Meroterpenoid natural products fromStreptomycesbacteria - the evolution of chemoenzymatic syntheses. Natural Product Reports, 37(10), 1334-1366. doi: 10.1039/d0np00018c
Alker, A. T., Delherbe, N., Purdy, T. N., Moore, B. S., & Shikuma, N. J. (2020). Genetic examination of the marine bacteriumPseudoalteromonas luteoviolaceaand effects of its metamorphosis-inducing factors. Environmental Microbiology. doi: 10.1111/1462-2920.15211
Zhang, J. J., & Moore, B. S. (2020). Site-Directed Mutagenesis of Large Biosynthetic Gene Clusters via Oligonucleotide Recombineering and CRISPR/Cas9 Targeting. Acs Synthetic Biology, 9(7), 1917-1922. doi: 10.1021/acssynbio.0c00265
Podell, S., Blanton, J. M., Oliver, A., Schorn, M. A., Agarwal, V., Biggs, J. S., ... Allen, E. E. (2020). A genomic view of trophic and metabolic diversity in clade-specific Lamellodysidea sponge microbiomes. Microbiome, 8. doi: 10.21203/rs.2.17204/v1
Chekan, O. R., McKinnie, S. M. K., Noel, J. P., & Moore, B. S. (2020). Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12799-12805. doi: 10.1073/pnas.2001325117
Tang, X. Y., Kudo, Y., Baker, J. L., LaBonte, S., Jordan, P. A., McKinnie, S. M. K., ... Edlund, A. (2020). Cariogenic Streptococcus mutans produces tetramic acid strain-specific antibiotics that impair commensal colonization. Acs Infectious Diseases, 6(4), 563-571. doi: 10.1021/acsinfecdis.9b00365
Sigrist, R., Luhavaya, H., McKinnie, S. M. K., da Silva, A. F., Jurberg, I. D., Moore, B. S., & de Oliveira, L. G. (2020). Nonlinear biosynthetic assembly of alpiniamide by a hybrid cis/trans-AT PKS-NRPS. Acs Chemical Biology, 15(4), 1067-1077. doi: 10.1021/acschembio.0c00081
Fiore, M. F., de Lima, S. T., Carmichael, W. W., McKinnie, S. M. K., Chekan, J. R., & Moore, B. S. (2020). Guanitoxin, re-naming a cyanobacterial organophosphate toxin. Harmful Algae, 92(101737). doi: 10.1016/j.hal.2019.101737
Zhang, J. J., Tang, X. Y., Huan, T., Ross, A. C., & Moore, B. S. (2020). Pass-back chain extension expands multimodular assembly line biosynthesis. Nature Chemical Biology, 16(1), 42-+. doi: 10.1038/s41589-019-0385-4

2019

Chekan, J. R., Lee, G. Y., El Gamal, A., Purdy, T. N., Houk, K. N., & Moore, B. S. (2019). Bacterial tetrabromopyrrole debrominase shares a reductive dehalogenation strategy with human thyroid deiodinase. Biochemistry, 58(52), 5329-5338. doi: 10.1021/acs.biochem.9b00318
Podell, S., Blanton, J. M., Neu, A., Agarwal, V., Biggs, J. S., Moore, B. S., & Allen, E. E. (2019). Pangenomic comparison of globally distributed Poribacteria associated with sponge hosts and marine particles. The ISME Journal. doi: 10.1038/s41396-018-0292-9
Li, Z. R., Li, J., Cai, W. L., Lai, J. Y. H., McKinnie, S. M. K., Zhang, W. P., ... Qian, P. Y. (2019). Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nature Chemistry, 11(10), 880-889. doi: 10.1038/s41557-019-0317-7
Zhang, J. J., Tang, X. Y., & Moore, B. S. (2019). Genetic platforms for heterologous expression of microbial natural products. Natural Product Reports, 36(9), 1313-1332. doi: 10.1039/c9np00025a
Valiadi, M., de Rond, T., Amorim, A., Gittins, J. R., Gubili, C., Moore, B. S., ... Latz, M. I. (2019). Molecular and biochemical basis for the loss of bioluminescence in the dinoflagellate Noctiluca scintillans along the west coast of the USA. Limnology and Oceanography. doi: 10.1002/lno.11309
Chekan, J. R., McKinnie, S. M. K., Moore, M. L., Poplawski, S. G., Michael, T. P., & Moore, B. S. (2019). Scalable biosynthesis of the seaweed neurochemical, kainic acid. Angewandte Chemie-International Edition, 58(25), 8454-8457. doi: 10.1002/anie.201902910
Luhavaya, H., Sigrist, R., Chekan, J. R., McKinnie, S. M. K., & Moore, B. S. (2019). Biosynthesis of l-4-chlorokynurenine, an antidepressant prodrug and a non-proteinogenic amino acid found in lipopeptide antibiotics. Angewandte Chemie-International Edition, 58(25), 8394-8399. doi: 10.1002/anie.201901571
Schorn, M. A., Jordan, P. A., Podell, S., Blanton, J. M., Agarwal, V., Biggs, J. S., ... Moore, B. S. (2019). Comparative genomics of cyanobacterial symbionts reveals distinct, specialized metabolism in tropical Dysideidae sponges. mBio, 10. doi: 10.1128/mBio.00821-19
Busch, J., Agarwal, V., Schorn, M., Machado, H., Moore, B. S., Rouse, G. W., ... Jensen, P. R. (2019). Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas. Environmental Microbiology, 21(5), 1575-1585. doi: 10.1111/1462-2920.14532
Walsh, C. T., & Moore, B. S. (2019). Enzymatic cascade reactions in biosynthesis. Angewandte Chemie-International Edition, 58(21), 6846-6879. doi: 10.1002/anie.201807844
Bauman, K. D., Li, J., Murata, K., Mantovani, S. M., Dahesh, S., Nizet, V., ... Moore, B. S. (2019). Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry. Cell Chemical Biology, 26(5), 724-+. doi: 10.1016/j.chembiol.2019.02.004
Rothe, M. L., Li, J., Garibay, E., Moore, B. S., & McKinnie, S. M. K. (2019). Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives. Organic & Biomolecular Chemistry, 17(13), 3416-3423. doi: 10.1039/c8ob03109f
Thapa, H. R., Robbins, J. M., Moore, B. S., & Agarwal, V. (2019). Insights into thiotemplated pyrrole biosynthesis gained from the crystal structure of flavin-dependent oxidase in complex with carrier protein. Biochemistry, 58(7), 918-929. doi: 10.1021/acs.biochem.8b01177
McAlpine, J. B., Chen, S. N., Kutateladze, A., MacMillan, J. B., Appendino, G., Barison, A., ... Pauli, G. F. (2019). The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports, 36(1), 35-107. doi: 10.1039/c7np00064b
Zhang, J. J., Yamanaka, K., Tang, X. Y., & Moore, B. S. (2019). Direct cloning and heterologous expression of natural product biosynthetic gene clusters by transformation-associated recombination. Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Pt A (pp. 87-110). San Diego: Elsevier Academic Press Inc. doi: 10.1016/bs.mie.2019.02.026

2018

McKinnie, S. M. K., Miles, Z. D., Jordan, P. A., Awakawa, T., Pepper, H. P., Murray, L. A. M., ... Moore, B. S. (2018). Total enzyme syntheses of napyradiomycins A1 and B1. Journal of the American Chemical Society, 140(51), 17840-17845. doi: 10.1021/jacs.8b10134
Schlawis, C., Kern, S., Kudo, Y., Grunenberg, J., Moore, B. S., & Schulz, S. (2018). Structural elucidation of trace components combining GC/MS, GC/IR, DFT-calculation and synthesis-salinilactones, unprecedented bicyclic lactones from Salinispora bacteria. Angewandte Chemie-International Edition, 57(45), 14921-14925. doi: 10.1002/anie.201807923
Zhang, J. J., Moore, B. S., & Tang, X. Y. (2018). Engineering Salinispora tropica for heterologous expression of natural product biosynthetic gene clusters. Applied Microbiology and Biotechnology, 102(19), 8437-8446. doi: 10.1007/s00253-018-9283-z
Whalen, K. E., Kirby, C., Nicholson, R. M., O'Reilly, M., Moore, B. S., & Harvey, E. L. (2018). The chemical cue tetrabromopyrrole induces rapid cellular stress and mortality in phytoplankton. Scientific Reports, 8(15498). doi: 10.1038/s41598-018-33945-3
Brunson, J. K., McKinnie, S. M. K., Chekan, J. R., McCrow, J. P., Miles, Z. D., Bertrand, E. M., ... Moore, B. S. (2018). Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom. Science, 361(6409), 1356-+. doi: 10.1126/science.aau0382
Murray, L. A. M., McKinnie, S. M. K., Pepper, H. P., Erni, R., Miles, Z. D., Cruickshank, M. C., ... George, J. H. (2018). Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products. Angewandte Chemie-International Edition, 57(34), 11009-11014. doi: 10.1002/anie.201804351
Saleem-Batcha, R., Stull, F., Sanders, J. N., Moore, B. S., Palfey, B. A., Houk, K. N., & Teufel, R. (2018). Enzymatic control of dioxygen binding and functionalization of the flavin cofactor. Proceedings of the National Academy of Sciences of the United States of America, 115(19), 4909-4914. doi: 10.1073/pnas.1801189115
Zheng, J., McKinnie, S. M. K., El Gama, A., Fengit, W., Dong, Y., Agarwal, V., ... Pessah, I. N. (2018). Organohalogens naturally biosynthesized in marine environments and produced as disinfection byproducts alter sarco/endoplasmic reticulum ca2+ dynamics. Environmental Science & Technology, 52(9), 5469-5478. doi: 10.1021/acs.est.8b00512
Moore, B. S. (2018). Asymmetric Alkene and Arene Halofunctionalization Reactions in Meroterpenoid Biosynthesis. Synlett, 29(4), 401-409. doi: 10.1055/s-0036-1590919
Reynolds, K. A., Luhavaya, H., Li, J., Dahesh, S., Nizet, V., Yamanaka, K., & Moore, B. S. (2018). Isolation and structure elucidation of lipopeptide antibiotic taromycin B from the activated taromycin biosynthetic gene cluster. Journal of Antibiotics, 71(2), 333-338. doi: 10.1038/ja.2017.146
Bruns, H., Crusemann, M., Letzel, A. C., Alanjary, M., McInerney, J. O., Jensen, P. R., ... Ziemert, N. (2018). Function-related replacement of bacterial siderophore pathways. Isme Journal, 12(2), 320-329. doi: 10.1038/ismej.2017.137
Chekan, J. R., & Moore, B. S. (2018). Preparation and characterization of tetrabromopyrrole debrominase from marine proteobacteria. Marine Enzymes and Specialized Metabolism, Pt B (pp. 253-265). San Diego: Elsevier Academic Press Inc. doi: 10.1016/bs.mie.2018.01.031
McKinnie, S. M. K., Miles, Z. D., & Moore, B. S. (2018). Characterization and biochemical assays of Streptomyces vanadium-dependent chloroperoxidases. Marine Enzymes and Specialized Metabolism, Pt A (pp. 405-424). San Diego: Elsevier Academic Press Inc. doi: 10.1016/bs.mie.2018.02.016

2017

Miles, Z. D., Diethelm, S., Pepper, H. P., Huang, D. M., George, J. H., & Moore, B. S. (2017). A unifying paradigm for naphthoquinone-based meroterpenoid (bio)synthesis. Nature Chemistry, 9(12), 1235-1242. doi: 10.1038/nchem.2829
Amos, G. C. A., Awakawa, T., Tuttle, R. N., Letzel, A. C., Kim, M. C., Kudo, Y., ... Jensen, P. R. (2017). Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11121-E11130. doi: 10.1073/pnas.1714381115
Letzel, A. C., Li, J., Amos, G. C. A., Millan-Aguinaga, N., Ginigini, J., Abdelmohsen, U. R., ... Jensen, P. R. (2017). Genomic insights into specialized metabolism in the marine actinomycete Salinispora. Environmental Microbiology, 19(9), 3660-3673. doi: 10.1111/1462-2920.13867
Li, J., Tang, X. Y., Awakawa, T., & Moore, B. S. (2017). Enzymatic C-H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity. Angewandte Chemie-International Edition, 56(40), 12234-12239. doi: 10.1002/anie.201705239
Zhang, J. J., Tang, X. Y., Zhang, M., Nguyen, D., & Moore, B. S. (2017). Broad-host-range expression reveals native and host regulatory elements that influence heterologous antibiotic production in gram-negative bacteria. Mbio, 8(5). doi: 10.1128/mBio.01291-17
Tang, X. Y., Li, J., & Moore, B. S. (2017). Minimization of the thiolactomycin biosynthetic pathway reveals that the cytochrome p450 enzyme tlmf is required for five-membered thiolactone ring formation. Chembiochem, 18(12), 1072-1076. doi: 10.1002/cbic.201700090
Larson, C. B., Crusemann, M., & Moore, B. S. (2017). PCR-independent method of transformation-associated recombination reveals the cosmomycin biosynthetic gene cluster in an ocean streptomycete. Journal of Natural Products, 80(4), 1200-1204. doi: 10.1021/acs.jnatprod.6b01121
Agarwal, V., Miles, Z. D., Winter, J. M., Eustaquio, A. S., El Gamal, A. A., & Moore, B. S. (2017). Enzymatic halogenation and dehalogenation reactions: Pervasive and mechanistically diverse. Chemical Reviews, 117(8), 5619-5674. doi: 10.1021/acs.chemrev.6b00571
Agarwal, V., Blanton, J. M., Podell, S., Taton, A., Schorn, M. A., Busch, J., ... Moore, B. S. (2017). Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nat Chem Biol, advance online publication. doi: 10.1038/nchembio.2330
Crusemann, M., O'Neill, E. C., Larson, C. B., Melnik, A. V., Floros, D. J., da Silva, R. R., ... Moore, B. S. (2017). Prioritizing natural product diversity in a collection of 146 bacterial strains based on growth and extraction protocols. Journal of Natural Products, 80(3), 588-597. doi: 10.1021/acsjnatprod.6b00722
Patin, N. V., Schorn, M., Aguinaldo, K., Lincecum, T., Moore, B. S., & Jensen, P. R. (2017). Effects of actinomycete secondary metabolites on sediment microbial communities. Applied and Environmental Microbiology, 83(4). doi: 10.1128/aem.02676-16
Nguyen, D. D., Melnik, A. V., Koyama, N., Lu, X. W., Schorn, M., Fang, J. S., ... Dorrestein, P. C. (2017). Indexing the Pseudomonas specialized metabolome enabled the discovery of poaeamide B and the bananamides. Nature Microbiology, 2(1). doi: 10.1038/nmicrobiol.2016.197

2016

Zhang, W. P., Lu, L., Lai, Q. L., Zhu, B. K., Li, Z. R., Xu, Y., ... Qian, P. Y. (2016). Family-wide structural characterization and genomic comparisons decode the diversity-oriented biosynthesis of thalassospiramides by marine proteobacteria. Journal of Biological Chemistry, 291(53), 27228-+. doi: 10.1074/jbc.M116.756858
Schorn, M. A., Alanjary, M. M., Aguinaldo, K., Korobeynikov, A., Podell, S., Patin, N., ... Moore, B. S. (2016). Sequencing rare marine actinomycete genomes reveals high density of unique natural product biosynthetic gene clusters. Microbiology-Sgm, 162(12), 2075-2086. doi: 10.1099/mic.0.000386
Jordan, P. A., & Moore, B. S. (2016). Biosynthetic pathway connects cryptic ribosomally synthesized posttranslationally modified peptide genes with pyrroloquinoline alkaloids. Cell Chemical Biology, 23(12), 1504-1514. doi: 10.1016/j.chembiol.2016.10.009
El Gamal, A., Agarwal, V., Rahman, I., & Moore, B. S. (2016). Enzymatic reductive dehalogenation controls the biosynthesis of marine bacterial pyrroles. Journal of the American Chemical Society, 138(40), 13167-13170. doi: 10.1021/jacs.6b08512
Groenhagen, U., De Oliveira, A. L. L., Fielding, E., Moore, B. S., & Schulz, S. (2016). Coupled biosynthesis of volatiles and salinosporamideA in Salinispora tropica. Chembiochem, 17(20), 1978-1985. doi: 10.1002/cbic.201600388
Li, Z. R., Li, J., Gu, J. P., Lai, J. Y. H., Duggan, B. M., Zhang, W. P., ... Qian, P. Y. (2016). Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin. Nature Chemical Biology, 12(10), 773-+. doi: 10.1038/nchembio.2157
Wang, M. X., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., ... Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology, 34(8), 828-837. doi: 10.1038/nbt.3597
Teufel, R., Agarwal, V., & Moore, B. S. (2016). Unusual flavoenzyme catalysis in marine bacteria. Current Opinion in Chemical Biology, 31, 31-39. doi: 10.1016/j.clopa.2016.01.001
El Gamal, A., Agarwal, V., Diethelm, S., Rahman, I., Schorn, M. A., Sneed, J. M., ... Moore, B. S. (2016). Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proceedings of the National Academy of Sciences of the United States of America, 113(14), 3797-3802. doi: 10.1073/pnas.1519695113
Harvey, E. L., Deering, R. W., Rowley, D. C., El Gamal, A., Schorn, M., Moore, B. S., ... Whalen, K. E. (2016). A bacterial quorum-sensing precursor induces mortality in the marine coccolithophore, Emiliania huxleyi. Frontiers in Microbiology, 7(59). doi: 10.3389/fmicb.2016.00059
Ray, L., Yamanaka, K., & Moore, B. S. (2016). A peptidyl-transesterifying type I thioesterase in salinamide biosynthesis. Angewandte Chemie-International Edition, 55(1), 364-367. doi: 10.1002/anie.201508576
Cha, J. Y., Han, S., Hong, H. J., Cho, H., Kim, D., Kwon, Y., ... Kwak, Y. S. (2016). Microbial and biochemical basis of a Fusarium wilt-suppressive soil. Isme Journal, 10(1), 119-129. doi: 10.1038/ismej.2015.95

2015

Tang, X. Y., Li, J., Millan-Aguinaga, N., Zhang, J. J., O'Neill, E. C., Ugalde, J. A., ... Moore, B. S. (2015). Identification of thiotetronic acid antibiotic biosynthetic pathways by target-directed genome mining. Acs Chemical Biology, 10(12), 2841-2849. doi: 10.1021/acschembio.5b00658
Agarwal, V., Diethelm, S., Ray, L., Garg, N., Awakawa, T., Dorrestein, P. C., & Moore, B. S. (2015). Chemoenzymatic synthesis of acyl coenzyme a substrates enables in situ labeling of small molecules and proteins. Organic Letters, 17(18), 4452-4455. doi: 10.1021/acs.orglett.5b02113
Kim, E., Moore, B. S., & Yoon, Y. J. (2015). Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nature Chemical Biology, 11(9), 649-659. doi: 10.1038/nchembio.1893
Awakawa, T., Crusemann, M., Munguia, J., Ziemert, N., Nizet, V., Fenical, W., & Moore, B. S. (2015). Salinipyrone and pacificanone are biosynthetic by-products of the rosamicin polyketide synthase. Chembiochem, 16(10), 1443-1447. doi: 10.1002/cbic.201500177
Teufel, R., Stull, F., Meehan, M. J., Michaudel, Q., Dorrestein, P. C., Palfey, B., & Moore, B. S. (2015). Biochemical establishment and characterization of EncM's flavin-N5-oxide cofactor. Journal of the American Chemical Society, 137(25), 8078-8085. doi: 10.1021/jacs.5b03983
Richter, T. K. S., Hughes, C. C., & Moore, B. S. (2015). Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway. Environmental Microbiology, 17(6), 2158-2171. doi: 10.1111/1462-2920.12669
Ross, A. C., Gulland, L. E. S., Dorrestein, P. C., & Moore, B. S. (2015). Targeted capture and heterologous expression of the pseudoalteromonas alterochromide gene cluster in Escherichia coil represents a promising natural product exploratory platform. ACS Synthetic Biology, 4(4), 414-420. doi: 10.1021/sb500280q
Duncan, K. R., Crusemann, M., Lechner, A., Sarkar, A., Li, J., Ziemert, N., ... Jensen, P. R. (2015). Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chemistry & Biology, 22(4), 460-471. doi: 10.1016/j.chembiol.2015.03.010
Lu, L., Meehan, M. J., Gu, S., Chen, Z., Zhang, W., Zhang, G., ... Qian, P. (2015). Mechanism of action of thalassospiramides, a new class of calpain inhibitors. Scientific Reports, 5(8783). doi: 10.1038/srep08783
Li, Y. X., Li, Z. R., Yamanaka, K., Xu, Y., Zhang, W. P., Vlamakis, H., ... Qian, P. Y. (2015). Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis. Scientific Reports, 5(9383). doi: 10.1038/srep09383
Bonet, B., Teufel, R., Crusemann, M., Ziemert, N., & Moore, B. S. (2015). Direct capture and heterologous expression of Salinispora natural product genes for the biosynthesis of enterocin. Journal of Natural Products, 78(3), 539-542. doi: 10.1021/np500664q
Agarwal, V., Li, J., Rahman, I., Borgen, M., Aluwihare, L. I., Biggs, J. S., ... Moore, B. S. (2015). Complexity of naturally produced polybrominated diphenyl ethers revealed via mass spectrometry. Environmental Science & Technology, 49(3), 1339-1346. doi: 10.1021/es505440j

2014

Diethelm, S., Teufel, R., Kaysser, L., & Moore, B. S. (2014). A multitasking vanadium-dependent chloroperoxidase as an inspiration for the chemical synthesis of the merochlorins. Angewandte Chemie-International Edition, 53(41), 11023-11026. doi: 10.1002/anie.201405696
Teufel, R., Kaysser, L., Villaume, M. T., Diethelm, S., Carbullido, M. K., Baran, P. S., & Moore, B. S. (2014). One-pot enzymatic synthesis of merochlorin A and B. Angewandte Chemie-International Edition, 53(41), 11019-11022. doi: 10.1002/anie.201405694
Xu, M. M., Hillwig, M. L., Lane, A. L., Tiernan, M. S., Moore, B. S., & Peters, R. J. (2014). Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. Journal of Natural Products, 77(9), 2144-2147. doi: 10.1021/np500422d
Agarwal, V., & Moore, B. S. (2014). Enzymatic synthesis of polybrominated dioxins from the marine environment. Acs Chemical Biology, 9(9), 1980-1984. doi: 10.1021/cb5004338
Mohimani, H., Liu, W. T., Kersten, R. D., Moore, B. S., Dorrestein, P. C., & Pevzner, P. A. (2014). NRPquest: Coupling mass spectrometry and genome mining for nonribosomal peptide discovery. Journal of Natural Products, 77(8), 1902-1909. doi: 10.1021/np500370c
Niewerth, D., Jansen, G., Riethoff, L. F. V., van Meerloo, J., Kale, A. J., Moore, B. S., ... Cloos, J. (2014). Antileukemic activity and mechanism of drug resistance to the marine Salinispora tropica proteasome inhibitor Salinosporamide A (Marizomib). Molecular Pharmacology, 86(1), 12-19. doi: 10.1124/mol.114.092114
Mohimani, H., Kersten, R. D., Liu, W. T., Wang, M. X., Purvine, S. O., Wu, S., ... Dorrestein, P. C. (2014). Automated genome mining of ribosomal peptide natural products. Acs Chemical Biology, 9(7), 1545-1551. doi: 10.1021/cb500199h
Agarwal, V., El Gamal, A. A., Yamanaka, K., Poth, D., Kersten, R. D., Schorn, M., ... Moore, B. S. (2014). Biosynthesis of polybrominated aromatic organic compounds by marine bacteria. Nat Chem Biol, 10(8), 640-647. doi: 10.1038/nchembio.1564
Trivella, D. B. B., Pereira, A. R., Stein, M. L., Kasai, Y., Byrum, T., Valeriote, F. A., ... Moore, B. S. (2014). Enzyme inhibition by hydroamination: Design and mechanism of a hybrid carmaphycin-syringolin enone proteasome inhibitor. Chemistry & Biology, 21(6), 782-791. doi: 10.1016/j.chembiol.2014.04.010
Jensen, P. R., Chavarria, K. L., Fenical, W., Moore, B. S., & Ziemert, N. (2014). Challenges and triumphs to genomics-based natural product discovery. Journal of Industrial Microbiology & Biotechnology, 41(2), 203-209. doi: 10.1007/s10295-013-1353-8
Yamanaka, K., Reynolds, K. A., Kersten, R. D., Ryan, K. S., Gonzalez, D. J., Nizet, V., ... Moore, B. S. (2014). Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proceedings of the National Academy of Sciences of the United States of America, 111(5), 1957-1962. doi: 10.1073/pnas.1319584111
Schorn, M., Zettler, J., Noel, J. P., Dorrestein, P. C., Moore, B. S., & Kaysser, L. (2014). Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. Acs Chemical Biology, 9(1), 301-309. doi: 10.1021/cb400699p

2013

Mantovani, S. M., & Moore, B. S. (2013). Flavin-linked oxidase catalyzes pyrrolizine formation of dichloropyrrole-containing polyketide extender unit in chlorizidine a. Journal of the American Chemical Society, 135(48), 18032-18035. doi: 10.1021/ja409520v
Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., ... van der Donk, W. A. (2013). Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports, 30(1), 108-160. doi: 10.1039/c2np20085f
Teufel, R., Miyanaga, A., Michaudel, Q., Stull, F., Louie, G., Noel, J. P., ... Moore, B. S. (2013). Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature, 503(7477), 552-+. doi: 10.1038/nature12643
Kersten, R. D., Ziemert, N., Gonzalez, D. J., Duggan, B. M., Nizet, V., Dorrestein, P. C., & Moore, B. S. (2013). Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proceedings of the National Academy of Sciences of the United States of America, 110(47), E4407-E4416. doi: 10.1073/pnas.1315492110
Horsman, G. P., Lechner, A., Ohnish, Y., Moore, B. S., & Shen, B. (2013). Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. Biochemistry, 52(31), 5217-5224. doi: 10.1021/bi400572a
Nguyen, D. D., Wu, C. H., Moree, W. J., Lamsa, A., Medema, M. H., Zhao, X. L., ... Dorrestein, P. C. (2013). MS/MS networking guided analysis of molecule and gene cluster families. Proceedings of the National Academy of Sciences of the United States of America, 110(28), E2611-E2620. doi: 10.1073/pnas.1303471110
Lechner, A., Wilson, M. C., Ban, Y. H., Hwang, J. Y., Yoon, Y. J., & Moore, B. S. (2013). Designed biosynthesis of 36-methyl-fk506 by polyketide precursor pathway engineering. Acs Synthetic Biology, 2(7), 379-383. doi: 10.1021/sb3001062
Lipson, J. M., Thomsen, M., Moore, B. S., Clausen, R. P., La Clair, J. J., & Burkart, M. D. (2013). A Tandem Chemoenzymatic Methylation by S-Adenosyl-L-methionine. ChemBioChem, 14(8), 950-953. doi: 10.1002/cbic.201300221
Kersten, R. D., Lane, A. L., Nett, M., Richter, T. K. S., Duggan, B. M., Dorrestein, P. C., & Moore, B. S. (2013). Bioactivity-Guided Genome Mining Reveals the Lomaiviticin Biosynthetic Gene Cluster in Salinispora tropica. ChemBioChem, 14(8), 955-962. doi: 10.1002/cbic.201300147
Lane, A. L., Nam, S. J., Fukuda, T., Yamanaka, K., Kauffman, C. A., Jensen, P. R., ... Moore, B. S. (2013). Structures and Comparative Characterization of Biosynthetic Gene Clusters for Cyanosporasides, Enediyne-Derived Natural Products from Marine Actinomycetes. Journal of the American Chemical Society, 135(11), 4171-4174. doi: 10.1021/ja311065v
Ross, A. C., Xu, Y., Lu, L., Kersten, R. D., Shao, Z. Z., Al-Suwailem, A. M., ... Moore, B. S. (2013). Biosynthetic Multitasking Facilitates Thalassospiramide Structural Diversity in Marine Bacteria. Journal of the American Chemical Society, 135(3), 1155-1162. doi: 10.1021/ja3119674

2012

Kale, A. J., & Moore, B. S. (2012). Molecular Mechanisms of Acquired Proteasome Inhibitor Resistance. Journal of Medicinal Chemistry, 55(23), 10317-10327. doi: 10.1021/jm300434z
Yang, J. Y., Phelan, V. V., Simkovsky, R., Watrous, J. D., Trial, R. M., Fleming, T. C., ... Dorrestein, P. C. (2012). Primer on Agar-Based Microbial Imaging Mass Spectrometry. Journal of Bacteriology, 194(22), 6023-6028. doi: 10.1128/jb.00823-12
Roberts, A. A., Schultz, A. W., Kersten, R. D., Dorrestein, P. C., & Moore, B. S. (2012). Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores. Fems Microbiology Letters, 335(2), 95-103. doi: 10.1111/j.1574-6968.2012.02641.x
Qian, Q., Schultz, A. W., Moore, B. S., & Tanner, M. E. (2012). Mechanistic Studies on CymD: A Tryptophan Reverse N-Prenyltransferase. Biochemistry, 51(39), 7733-7739. doi: 10.1021/bi3009054
Richter, M., Busch, B., Ishida, K., Moore, B. S., & Hertweck, C. (2012). Pyran Formation by an Atypical CYP-Mediated Four-Electron Oxygenation-Cyclization Cascade in an Engineered Aureothin Pathway. Chembiochem, 13(15), 2196-2199. doi: 10.1002/Cbic.201200406
Yamanaka, K., Ryan, K. S., Gulder, T. A. M., Hughes, C. C., & Moore, B. S. (2012). Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis. Journal of the American Chemical Society, 134(30), 12434-12437. doi: 10.1021/ja305670f
Kaysser, L., Bernhardt, P., Nam, S. J., Loesgen, S., Ruby, J. G., Skewes-Cox, P., ... Moore, B. S. (2012). Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases. Journal of the American Chemical Society, 134(29), 11988-11991. doi: 10.1021/ja305665f
Watrous, J., Roach, P., Alexandrov, T., Heath, B. S., Yang, J. Y., Kersten, R. D., ... Dorrestein, P. C. (2012). Mass spectral molecular networking of living microbial colonies. Proceedings of the National Academy of Sciences of the United States of America, 109(26), E1743-E1752. doi: 10.1073/pnas.1203689109
Xu, Y., Kersten, R. D., Nam, S. J., Lu, L., Al-Suwailem, A. M., Zheng, H. J., ... Qian, P. Y. (2012). Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. Journal of the American Chemical Society, 134(20), 8625-8632. doi: 10.1021/ja301735a
Pereira, A. R., Kale, A. J., Fenley, A. T., Byrum, T., Debonsi, H. M., Gilson, M. K., ... Gerwick, W. H. (2012). The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. Chembiochem, 13(6), 810-817. doi: 10.1002/Cbic.201200007
Jones, A. C., Ottilie, S., Eustaquio, A. S., Edwards, D. J., Gerwick, L., Moore, B. S., & Gerwick, W. H. (2012). Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS Journal, 279(7), 1243-1251. doi: 10.1111/j.1742-4658.2012.08517.x
Chen, Z. H., Wang, B. L., Kale, A. J., Moore, B. S., Wang, R. W., & Qing, F. L. (2012). Coupling of sterically hindered aldehyde with fluorinated synthons: Stereoselective synthesis of fluorinated analogues of salinosporamide A. Journal of Fluorine Chemistry, 136, 12-19. doi: 10.1016/j.jfluchem.2012.01.003
Gonzalez, D. J., Okumura, C. Y., Hollands, A., Kersten, R., Akong-Moore, K., Pence, M. A., ... Nizet, V. (2012). Novel Phenol-soluble Modulin Derivatives in Community-associated Methicillin-resistant Staphylococcus aureus Identified through Imaging Mass Spectrometry. Journal of Biological Chemistry, 287(17), 13889-13898. doi: 10.1074/jbc.M112.349860
Gerwick, W. H., & Moore, B. S. (2012). Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chemistry & Biology, 19(1), 85-98. doi: 10.1016/j.chembiol.2011.12.014
Wilson, M. C., & Moore, B. S. (2012). Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. Natural Product Reports, 29(1), 72-86. doi: 10.1039/c1np00082a

2011

Lechner, A., Eustaquio, A. S., Gulder, T. A. M., Hafner, M., & Moore, B. S. (2011). Selective Overproduction of the Proteasome Inhibitor Salinosporamide A via Precursor Pathway Regulation. Chemistry & Biology, 18(12), 1527-1536. doi: 10.1016/j.chembiol.2011.10.014
Liu, W. T., Kersten, R. D., Yang, Y. L., Moore, B. S., & Dorrestein, P. C. (2011). Imaging Mass Spectrometry and Genome Mining via Short Sequence Tagging Identified the Anti-Infective Agent Arylomycin in Streptomyces roseosporus. Journal of the American Chemical Society, 133(45), 18010-18013. doi: 10.1021/ja2040877
Kalaitzis, J. A., Cheng, Q., Meluzzi, D., Xiang, L. K., Izumikawa, M., Dorrestein, P. C., & Moore, B. S. (2011). Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorganic & Medicinal Chemistry, 19(22), 6633-6638. doi: 10.1016/j.bmc.2011.04.024
Kersten, R. D., Yang, Y. L., Xu, Y. Q., Cimermancic, P., Nam, S. J., Fenical, W., ... Dorrestein, P. C. (2011). A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nature Chemical Biology, 7(11), 794-802. doi: 10.1038/nchembio.684
Kale, A. J., McGlinchey, R. P., Lechner, A., & Moore, B. S. (2011). Bacterial Self-Resistance to the Natural Proteasome Inhibitor Salinosporamide A. Acs Chemical Biology, 6(11), 1257-1264. doi: 10.1021/cb2002544
Miyanaga, A., Janso, J. E., McDonald, L., He, M., Liu, H. B., Barbieri, L., ... Moore, B. S. (2011). Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora Bacteria. Journal of the American Chemical Society, 133(34), 13311-13313. doi: 10.1021/ja205655w
Udwary, D. W., Gontang, E. A., Jones, A. C., Jones, C. S., Schultz, A. W., Winter, J. M., ... Moore, B. S. (2011). Significant natural product biosynthetic potential of actinorhizal symbionts of the genus Frankia, as revealed by comparative genomic and proteomic analyses. Applied and Environmental Microbiology, 77(11), 3617-3625. doi: 10.1128/aem.00038-11
Bernhardt, P., Okino, T., Winter, J. M., Miyanaga, A., & Moore, B. S. (2011). A Stereoselective Vanadium-Dependent Chloroperoxidase in Bacterial Antibiotic Biosynthesis. Journal of the American Chemical Society, 133(12), 4268-4270. doi: 10.1021/ja201088k
Wilson, M. C., Nam, S. J., Gulder, T. A. M., Kauffman, C. A., Jensen, P. R., Fenical, W., & Moore, B. S. (2011). Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. Journal of the American Chemical Society, 133(6), 1971-1977. doi: 10.1021/ja109226s
Mo, S., Kim, D. H., Lee, J. H., Park, J. W., Basnet, D. B., Ban, Y. H., ... Yoon, Y. J. (2011). Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues. Journal of the American Chemical Society, 133(4), 976-985. doi: 10.1021/ja108399b
Eustaquio, A. S., Nam, S. J., Penn, K., Lechner, A., Wilson, M. C., Fenical, W., ... Moore, B. S. (2011). The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution. Chembiochem, 12(1), 61-64. doi: 10.1002/cbic.201000564
Yang, Y. L., Xu, Y. Q., Kersten, R. D., Liu, W. T., Meehan, M. J., Moore, B. S., ... Dorrestein, P. C. (2011). Connecting Chemotypes and Phenotypes of Cultured Marine Microbial Assemblages by Imaging Mass Spectrometry. Angewandte Chemie-International Edition, 50(26), 5839-5842. doi: 10.1002/anie.201101225
Lane, A. L., & Moore, B. S. (2011). A sea of biosynthesis: marine natural products meet the molecular age. Natural Product Reports, 28(2), 411-428. doi: 10.1039/c0np90032j

2010

Kale, A. J., McGlinchey, R. P., & Moore, B. S. (2010). Characterization of 5-Chloro-5-Deoxy-D-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis SUBSTRATE AND REACTION PROFILING. Journal of Biological Chemistry, 285(44), 33710-33717. doi: 10.1074/jbc.M110.153833
Mahlstedt, S., Fielding, E. N., Moore, B. S., & Walsh, C. T. (2010). Prephenate Decarboxylases: A New Prephenate-Utilizing Enzyme Family That Performs Nonaromatizing Decarboxylation en Route to Diverse Secondary Metabolites. Biochemistry, 49(42), 9021-9023. doi: 10.1021/bi101457h
Wilson, M. C., Gulder, T. A. M., Mahmud, T., & Moore, B. S. (2010). Shared Biosynthesis of the Saliniketals and Rifamycins in Salinispora arenicola is Controlled by the sare1259-Encoded Cytochrome P450. Journal of the American Chemical Society, 132(36), 12757-12765. doi: 10.1021/ja105891a
Werneburg, M., Busch, B., He, J., Richter, M. E. A., Xiang, L. K., Moore, B. S., ... Hertweck, C. (2010). Exploiting Enzymatic Promiscuity to Engineer a Focused Library of Highly Selective Antifungal and Antiproliferative Aureothin Analogues. Journal of the American Chemical Society, 132(30), 10407-10413. doi: 10.1021/ja102751h
Schultz, A. W., Lewis, C. A., Luzung, M. R., Baran, P. S., & Moore, B. S. (2010). Functional Characterization of the Cyclomarin/Cyclomarazine Prenyltransferase CymD Directs the Biosynthesis of Unnatural Cyclic Peptides. Journal of Natural Products, 73(3), 373-377. doi: 10.1021/np9006876
Eustaquio, A. S., O'Hagan, D., & Moore, B. S. (2010). Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide. Journal of Natural Products, 73(3), 378-382. doi: 10.1021/np900719u
Roberts, A. A., Ryan, K. S., Moore, B. S., & Gulder, T. A. M. (2010). Total (Bio)Synthesis: Strategies of Nature and of Chemists. Natural Products Via Enzymatic Reactions (pp. 149-203). Berlin: Springer-Verlag Berlin. doi: 10.1007/128_2010_79
Gulder, T. A. M., & Moore, B. S. (2010). Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics. Angewandte Chemie-International Edition, 49(49), 9346-9367. doi: 10.1002/anie.201000728

2009

Penn, K., Jenkins, C., Nett, M., Udwary, D. W., Gontang, E. A., McGlinchey, R. P., ... Jensen, P. R. (2009). Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. Isme Journal, 3(10), 1193-1203. doi: 10.1038/ismej.2009.58
Nett, M., Guider, T. A. M., Kale, A. J., Hughes, C. C., & Moore, B. S. (2009). Function-Oriented Biosynthesis of beta-Lactone Proteasome Inhibitors in Salinispora tropica. Journal of Medicinal Chemistry, 52(19), 6163-6167. doi: 10.1021/Jm901098m
Deng, H., McMahon, S. A., Eustaquio, A. S., Moore, B. S., Naismith, J. H., & O'Hagan, D. (2009). Mechanistic Insights into Water Activation in SAM Hydroxide Adenosyltransferase (duf-62). Chembiochem, 10(15), 2455-2459. doi: 10.1002/cbic.200900369
Liu, Y., Hazzard, C., Eustaquio, A. S., Reynolds, K. A., & Moore, B. S. (2009). Biosynthesis of Salinosporamides from alpha,beta-Unsaturated Fatty Acids: Implications for Extending Polyketide Synthase Diversity. Journal of the American Chemical Society, 131(30), 10376-+. doi: 10.1021/ja9042824
Winter, J. M., & Moore, B. S. (2009). Exploring the Chemistry and Biology of Vanadium-dependent Haloperoxidases. Journal of Biological Chemistry, 284(28), 18577-18581. doi: 10.1074/jbc.R109.001602
Eustaquio, A. S., McGlinchey, R. P., Liu, Y., Hazzard, C., Beer, L. L., Florova, G., ... Moore, B. S. (2009). Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proceedings of the National Academy of Sciences of the United States of America, 106(30), 12295-12300. doi: 10.1073/pnas.0901237106
Nett, M., & Moore, B. S. (2009). Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica. Pure and Applied Chemistry, 81(6), 1075-1084. doi: 10.1351/pac-con-08-08-08
Gulder, T. A. M., & Moore, B. S. (2009). Chasing the treasures of the sea - bacterial marine natural products. Current Opinion in Microbiology, 12(3), 252-260. doi: 10.1016/j.mib.2009.05.002
Liu, W. T., Ng, J., Meluzzi, D., Bandeira, N., Gutierrez, M., Simmons, T. L., ... Dorrestein, P. C. (2009). Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Analytical Chemistry, 81(11), 4200-4209. doi: 10.1021/ac900114t
Kalaitzis, J. A., Cheng, Q., Thomas, P. M., Kelleher, N. L., & Moore, B. S. (2009). In Vitro Biosynthesis of Unnatural Enterocin and Wailupemycin Polyketides. Journal of Natural Products, 72(3), 469-472. doi: 10.1021/np800598t
Nett, M., Ikeda, H., & Moore, B. S. (2009). Genomic basis for natural product biosynthetic diversity in the actinomycetes. Natural Product Reports, 26(11), 1362-1384. doi: 10.1039/b817069j
Winter, J. M., Jansma, A. L., Handel, T. M., & Moore, B. S. (2009). Formation of the Pyridazine Natural Product Azamerone by Biosynthetic Rearrangement of an Aryl Diazoketone. Angewandte Chemie-International Edition, 48(4), 767-770. doi: 10.1002/anie.200805140

2008

Eustaquio, A. S., Harle, J., Noel, J. P., & Moore, B. S. (2008). S-Adenosyl-L-Methionine Hydrolase (Adenosine-Forming), a Conserved Bacterial and Archeal Protein Related to SAM-Dependent Halogenases. Chembiochem, 9(14), 2215-2219. doi: 10.1002/cbic.200800341
Worthington, A. S., Hur, G. H., Meier, J. L., Cheng, Q., Moore, B. S., & Burkart, M. D. (2008). Probing the compatibility of type II ketosynthase-carrier protein partners. Chembiochem, 9(13), 2096-2103. doi: 10.1002/cbic.200800198
Moore, B. S., Eustaquio, A. S., & McGlinchey, R. P. (2008). Advances in and applications of proteasome inhibitors. Current Opinion in Chemical Biology, 12(4), 434-440. doi: 10.1016/j.cbpa.2008.06.033
McGlinchey, R. P., Nett, M., Eustaquio, A. S., Asolkar, R. N., Fenical, W., & Moore, B. S. (2008). Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. Journal of the American Chemical Society, 130(25), 7822-+. doi: 10.1021/ja8029398
Schultz, A. W., Oh, D. C., Carney, J. R., Williamson, R. T., Udwary, D. W., Jensen, P. R., ... Moore, B. S. (2008). Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. Journal of the American Chemical Society, 130(13), 4507-4516. doi: 10.1021/ja711188x
McGlinchey, R. P., Nett, M., & Moore, B. S. (2008). Unraveling the biosynthesis of the sporolide cyclohexenone building block. Journal of the American Chemical Society, 130(8), 2406-2407. doi: 10.1021/ja710488m
Eustaquio, A. S., Pojer, F., Noe, J. P., & Moore, B. S. (2008). Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nature Chemical Biology, 4(1), 69-74. doi: 10.1038/nchembio.2007.56
Udwary, D. W., Kalaitzis, J. A., & Moore, B. S. (2008). Emerging marine biotechnologies – Cloning of marine biosynthetic gene clusters. Oceans and human health (pp. 507-524). Amsterdam ; Boston: Elsevier.
Eustaquio, A. S., & Moore, B. S. (2008). Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome. Angewandte Chemie-International Edition, 47(21), 3936-3938. doi: 10.1002/anie.200800177
Moore, B. S. (2008). Extending the Biosynthetic Repertoire in Ribosomal Peptide Assembly. Angewandte Chemie-International Edition, 47(49), 9386-9388. doi: 10.1002/anie.200803868

2007

Cheng, Q., Xiang, L., Izumikawa, M., Meluzzi, D., & Moore, B. S. (2007). Enzymatic total synthesis of enterocin polyketides. Nature Chemical Biology, 3(9), 557-558. doi: 10.1038/nchembio.2007.22
Winter, J. M., Moffitt, M. C., Zazopoulos, E., McAlpine, J. B., Dorrestein, P. C., & Moore, B. S. (2007). Molecular basis for chloronium-mediated meroterpene cyclization - Cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. Journal of Biological Chemistry, 282(22), 16362-16368. doi: 10.1074/jbc.M611046200
Udwary, D. W., Zeigler, L., Asolkar, R. N., Singan, V., Lapidus, A., Fenical, W., ... Moore, B. S. (2007). Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proceedings of the National Academy of Sciences of the United States of America, 104(25), 10376-10381. doi: 10.1073/pnas.0700962104
Beer, L. L., & Moore, B. S. (2007). Biosynthetic convergence of salinosporamides A and B in the marine actinomycete Salinispora tropica. Organic Letters, 9(5), 845-848. doi: 10.1021/ol063102o
Moffitt, M. C., Louie, G. V., Bowman, M. E., Pence, J., Noel, J. P., & Moore, B. S. (2007). Discovery of two cyanobacterial phenylalanine ammonia lyases: Kinetic and structural characterization. Biochemistry, 46(4), 1004-1012. doi: 10.1021/bi061774g

2006

Louie, G. V., Bowman, M. E., Moffitt, M. C., Baiga, T. J., Moore, B. S., & Noel, J. P. (2006). Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chemistry & Biology, 13(12), 1327-1338. doi: 10.1016/j.chembiol.2006.11.011
Song, L. J., Barona-Gomez, F., Corre, C., Xiang, L. K., Udwary, D. W., Austin, M. B., ... Challis, G. L. (2006). Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. Journal of the American Chemical Society, 128(46), 14754-14755. doi: 10.1021/ja065247w
Austin, M. B., Saito, T., Bowman, M. E., Haydock, S., Kato, A., Moore, B. S., ... Noel, J. P. (2006). Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid - type III polyketide synthase. Nature Chemical Biology, 2(9), 494-502. doi: 10.1038/nchembio811
Izumikawa, W., Cheng, Q., & Moore, B. S. (2006). Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism. Journal of the American Chemical Society, 128(5), 1428-1429. doi: 10.1021/ja0559707
Moore, B. S. (2006). Biosynthesis of marine natural products: macroorganisms (Part B). Natural Product Reports, 23(4), 615-629. doi: 10.1039/b508781n
Hicks, L. M., Moffitt, M. C., Beer, L. L., Moore, B. S., & Kelleher, N. L. (2006). Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. Acs Chemical Biology, 1(2), 93-102. doi: 10.1021/cb500007v

2005

Xiang, L. K., & Moore, B. S. (2005). Biochemical characterization of a prokaryotic phenylalanine ammonia lyase. Journal of Bacteriology, 187(12), 4286-4289. doi: 10.1128/jb.187.12.4286-4289.2005
Zhao, B., Guengerich, F. P., Bellamine, A., Lamb, D. C., Izumikawa, M., Lei, L., ... Waterman, M. R. (2005). Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. Journal of Biological Chemistry, 280(12), 11599-11607. doi: 10.1074/jbc.M410933200
Moore, B. S., Kalaitzis, J. A., & Xiang, L. K. (2005). Exploiting marine actinomycete biosynthetic pathways for drug discovery. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 87(1), 49-57. doi: 10.1007/s10482-004-6541-0
Moore, B. S. (2005). Biosynthesis of marine natural products: microorganisms (Part A). Natural Product Reports, 22(5), 580-593. doi: 10.1039/b404737k

2004

Xiang, L., Kalaitzis, J. A., & Moore, B. S. (2004). EncM, a versatile enterocin biosynthetic enzyme involved in Favorskii oxidative rearrangement, aldol condensation, and heterocycle-forming reactions. Proceedings of the National Academy of Sciences of the United States of America, 101(44), 15609-15614. doi: 10.1073/pnas.0405508101
Austin, M. B., Izumikawa, M., Bowman, M. E., Udwary, D. W., Ferrer, J. L., Moore, B. S., & Noel, J. P. (2004). Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. Journal of Biological Chemistry, 279(43), 45162-45174. doi: 10.1074/jbc.M406567200
Garcia-Bernardo, J., Xiang, L. K., Hong, H., Moore, B. S., & Leadlay, P. F. (2004). Engineered biosynthesis of phenyl-substituted polyketides. Chembiochem, 5(8), 1129-1131. doi: 10.1002/cbic.200400007
Kalaitzis, J. A., & Moore, B. S. (2004). Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase. Journal of Natural Products, 67(8), 1419-1422. doi: 10.1021/np0499564
Hertweck, C., Xiang, L. K., Kalaitzis, J. A., Cheng, Q., Palzer, M., & Moore, B. S. (2004). Context-dependent behavior of the enterocin iterative polyketide synthase: A new model for ketoreduction. Chemistry & Biology, 11(4), 461-468. doi: 10.1016/j.chembiol.2004.03.018
Becker, J. E., Moore, R. E., & Moore, B. S. (2004). Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization. Gene, 325, 35-42. doi: 10.1016/j.gene.2003.09.034

2003

Kalaitzis, J. A., Hamano, Y., Nilsen, G., & Moore, B. S. (2003). Biosynthesis and structural revision of neomarinone. Organic Letters, 5(23), 4449-4452. doi: 10.1021/ol035748b
Izumikawa, M., Shipley, P. R., Hopke, J. N., O'Hare, T., Xiang, L. K., Noel, J. P., & Moore, B. S. (2003). Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). Journal of Industrial Microbiology & Biotechnology, 30(8), 510-515. doi: 10.1007/s10295-003-0075-8
Kalaitzis, J. A., Izumikawa, M., Xiang, L. K., Hertweck, C., & Moore, B. S. (2003). Mutasynthesis of enterocin and wailupemycin analogues. Journal of the American Chemical Society, 125(31), 9290-9291. doi: 10.1021/ja035973o
Hoffmann, D., Hevel, J. M., Moore, R. E., & Moore, B. S. (2003). Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp GSV224. Gene, 311, 171-180. doi: 10.1016/s0378-1119(03)00587-0
Xiang, L. K., & Moore, B. S. (2003). Characterization of benzoyl coenzyme a biosynthesis genes in the enterocin-producing bacterium "Streptomyces maritimus". Journal of Bacteriology, 185(2), 399-404. doi: 10.1128/jb.185.2.399-404.2003

2002

Moore, B. S., Hertweck, C., Hopke, J. N., Izumikawa, M., Kalaitzis, J. A., Nilsen, G., ... Noel, J. P. (2002). Plant-like biosynthetic pathways in bacteria: From benzoic acid to chalcone. Journal of Natural Products, 65(12), 1956-1962. doi: 10.1021/np020230m
Hentschel, U., Hopke, J., Horn, M., Friedrich, A. B., Wagner, M., Hacker, J., & Moore, B. S. (2002). Molecular evidence for a uniform microbial community in sponges from different oceans. Applied and Environmental Microbiology, 68(9), 4431-4440. doi: 10.1128/aem.68.9.4431-4440.2002
Xiang, L. K., & Moore, B. S. (2002). Inactivation, complementation, and heterologous expression of encP, a novel bacterial phenylalanine ammonia-lyase gene. Journal of Biological Chemistry, 277(36), 32505-32509. doi: 10.1074/jbc.M204171200
Xiang, L. K., Kalaitzis, J. A., Nilsen, G., Chen, L., & Moore, B. S. (2002). Mutational analysis of the enterocin Favorskii biosynthetic rearrangement. Organic Letters, 4(6), 957-960. doi: 10.1021/ol0255155
Moore, B. S. (2002). The Interface of Natural Product Chemistry and Biology. Marine biotechnology in the twenty-first century : problems, promise, and products (pp. 61-64). Washington, DC: National Academy Press.
Moore, B. S., & Hertweck, C. (2002). Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Natural Product Reports, 19(1), 70-99. doi: 10.1039/b003939j

2001

Hertweck, C., Jarvis, A. P., Xiang, L. K., Moore, B. S., & Oldham, N. J. (2001). A mechanism of benzoic acid biosynthesis in plants and bacteria that mirrors fatty acid beta-oxidation. Chembiochem, 2(10), 784-+. doi: 10.1002/1439-7633(20011001)2:10<784::aid-cbic784>3.0.co;2-k
Moore, B. S., & Hopke, J. N. (2001). Discovery of a new bacterial polyketide biosynthetic pathway. Chembiochem, 2(1), 35-38. doi: 10.1002/1439-7633(20010105)2:1<35::aid-cbic35>3.0.co;2-1

2000

Moore, B. S., & Piel, J. (2000). Engineering biodiversity with type II polyketide synthase genes. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology, 78(3-4), 391-398.
Piel, J., Hertweck, C., Shipley, P. R., Hunt, D. M., Newman, M. S., & Moore, B. S. (2000). Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. Chemistry & Biology, 7(12), 943-955. doi: 10.1016/s1074-5521(00)00044-2
Hertweck, C., & Moore, B. S. (2000). A plant-like biosynthesis of benzoyl-CoA in the marine bacterium 'Streptomyces maritimus'. Tetrahedron, 56(46), 9115-9120. doi: 10.1016/s0040-4020(00)00765-1
Piel, J., Hoang, K., & Moore, B. S. (2000). Natural metabolic diversity encoded by the enterocin biosynthesis gene cluster. Journal of the American Chemical Society, 122(22), 5415-5416. doi: 10.1021/ja000445n

1999

Yu, T. W., Shen, Y. M., Doi-Katayama, Y., Tang, L., Park, C., Moore, B. S., ... Floss, H. G. (1999). Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. Proceedings of the National Academy of Sciences of the United States of America, 96(16), 9051-9056. doi: 10.1073/pnas.96.16.9051
Shen, Y. M., Yoon, P., Yu, T. W., Floss, H. G., Hopwood, D., & Moore, B. S. (1999). Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes. Proceedings of the National Academy of Sciences of the United States of America, 96(7), 3622-3627. doi: 10.1073/pnas.96.7.3622
Moore, B. S., Trischman, J. A., Seng, D., Kho, D., Jensen, P. R., & Fenical, W. (1999). Salinamides, antiinflammatory depsipeptides from a marine streptomycete. Journal of Organic Chemistry, 64(4), 1145-1150. doi: 10.1021/jo9814391
Moore, B. S., & Floss, H. G. (1999). Biosynthesis of Cyclic Fatty Acids Containing Cyclopropyl-, Cyclopentyl-, Cyclohexyl-, and Cycloheptyl-rings. Comprehensive Natural Products Chemistry (pp. 61-82). Oxford: Pergamon. doi: 10.1016/B978-0-08-091283-7.00002-3
Doi-Katayama, Y., Tang, L., Park, C., Yu, T. W., Moore, B., Floss, H. G., & Hutchinson, C. R. (1999). Biosynthesis of the Ansamycin Antibiotic Rifamycin: Polyketide Synthase Processes Multiple Polyketide Chains Simultaneously. Symposium on the Chemistry of Natural Products
Moore, B. S. (1999). Biosynthesis of marine natural products: microorganisms and macroalgae. Natural Product Reports, 16(6), 653-674. doi: 10.1039/a805873c

1998

Yu, T. W., Shen, Y. M., McDaniel, R., Floss, H. G., Khosla, C., Hopwood, D. A., & Moore, B. S. (1998). Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases. Journal of the American Chemical Society, 120(31), 7749-7759. doi: 10.1021/ja9803658
Moore, B. S., & Seng, D. (1998). Biosynthesis of the bicyclic depsipeptide salinamide A in Streptomyces sp. CNB-091: Origin of the carbons. Tetrahedron Letters, 39(23), 3915-3918. doi: 10.1016/s0040-4039(98)00726-6
Moore, B. S. (1998). "Biosynthetic Studies on the Salinamides, Depsipeptides from a Marine Streptomyces". New Developments in Marine Biotechnology (pp. xvi, 343 p.). New York: Plenum Press.

1997

Moore, B. S., Walker, K., Tornus, I., Handa, S., Poralla, K., & Floss, H. G. (1997). Biosynthetic studies of omega-cycloheptyl fatty acids in Alicyclobacillus cycloheptanicus. Formation of cycloheptanecarboxylic acid from phenylacetic acid. Journal of Organic Chemistry, 62(7), 2173-2185. doi: 10.1021/Jo962402o

1995

Moore, B. S., Eisenberg, R., Weber, C., Bridges, A., Nanz, D., & Robinson, J. A. (1995). On the Stereospecificity of the Coenzyme B-12-Dependent Isobutyryl-Coa Mutase Reaction. Journal of the American Chemical Society, 117(45), 11285-11291. doi: 10.1021/ja00150a028
Skubatz, H., Svee, E. R., Moore, B. S., Howald, W. N., Tang, W., & Meeuse, B. (1995). Oleic Acid and Its Positional Isomer, cis-Vaccinic Acid, in the Appendix of Sauromatum guttatum during Anthesis. Plant Physiol, 107(4), 1433-1438.
Moore, B. S., Floss, H. G., & Poralla, K. (1995). 3 New Omega-Cycloheptyl Fatty-Acids from Alicyclobacillus-Cycloheptanicus and Their Biosynthetic Interrelationships. Journal of Natural Products-Lloydia, 58(4), 590-593. doi: 10.1021/np50118a019
Floss, H. G., Kim, C., & Moore, B. (1995). New Variants of the Shikimate Pathway in the Biosynthesis of Antibiotics and Other Microbial Metabolites. Sekundärmetabolismus Bei Mikroorganismen: Beiträge Zur Forschung. Tübingen, Germany: Attempto-Verlag.

1994

Wallace, K. K., Reynolds, K. A., Koch, K., McArthur, H. A. I., Brown, M. S., Wax, R. G., & Moore, B. S. (1994). Biosynthetic-Studies of Ascomycin (Fk520) - Formation of the (1r,3r,4r)-3,4-Dihydroxycyclohexanecarboxylic Acid-Derived Moiety. Journal of the American Chemical Society, 116(25), 11600-11601. doi: 10.1021/ja00104a063
Moore, B. S., & Floss, H. G. (1994). Biosynthetic-Studies on the Origin of the Cyclohexanecarboxylic Acid Moiety of Ansatrienin-a and Omega-Cyclohexyl Fatty-Acids. Journal of Natural Products, 57(3), 382-386. doi: 10.1021/np50105a008

1993

Pratum, T. K., & Moore, B. S. (1993). Inverse Detection of C-13 Multiple-Quantum Coherence for Biosynthetic-Studies. Journal of Magnetic Resonance Series B, 102(1), 91-97. doi: 10.1006/jmrb.1993.1067
Moore, B. S., Cho, H. J., Casati, R., Kennedy, E., Reynolds, K. A., Mocek, U., ... Floss, H. G. (1993). Biosynthetic-Studies on Ansatrienin-a - Formation of the Cyclohexanecarboxylic Acid Moiety. Journal of the American Chemical Society, 115(12), 5254-5266. doi: 10.1021/ja00065a042
Moore, R. E., Ohtani, I., Moore, B. S., Dekoning, C. B., Yoshida, W. Y., Runnegar, M. T. C., & Carmichael, W. W. (1993). Cyanobacterial Toxins. Gazzetta Chimica Italiana, 123(6), 329-336.
Moore, B. S., Poralla, K., & Floss, H. G. (1993). Biosynthesis of the Cyclohexanecarboxylic Acid Starter Unit of Omega-Cyclohexyl Fatty-Acids in Alicyclobacillus-Acidocaldarius. Journal of the American Chemical Society, 115(12), 5267-5274. doi: 10.1021/ja00065a043

1992

Moore, B. S., Ohtani, I., Dekoning, C. B., Moore, R. E., & Carmichael, W. W. (1992). Biosynthesis of Anatoxin-a(S) - Origin of the Carbons. Tetrahedron Letters, 33(44), 6595-6598. doi: 10.1016/S0040-4039(00)60994-2
Moore, B. S., Chen, J. L., Patterson, G. M. L., & Moore, R. E. (1992). Structures of Cylindrocyclophanes a-F. Tetrahedron, 48(15), 3001-3006. doi: 10.1016/s0040-4020(01)92244-6
Floss, H. G., Cho, H., Casati, R., Reynolds, K. A., Kennedy, E., Moore, B. S., ... Poralla, K. (1992). Diversions of the Shikimate Pathway — The Biosynthesis of Cyclohexanecarboxylic Acid. Secondary-Metabolite Biosynthesis and Metabolism (pp. 77-88). : Springer US. doi: 10.1007/978-1-4615-3012-1_6

1991

Moore, R. E., Chen, J. L., Moore, B. S., Patterson, G. M. L., & Carmichael, W. W. (1991). Biosynthesis of Microcystin-Lr - Origin of the Carbons in the Adda and Masp Units. Journal of the American Chemical Society, 113(13), 5083-5084. doi: 10.1021/Ja00013a066

1990

Moore, B. S., Chen, J. L., Patterson, G. M. L., Moore, R. E., Brinen, L. S., Kato, Y., & Clardy, J. (1990). 7.7 Paracyclophanes from Blue-Green-Algae. Journal of the American Chemical Society, 112(10), 4061-4063. doi: 10.1021/ja00166a066

1989

Moore, R. E., Banarjee, S., Bornemann, V., Caplan, F. R., Chen, J. L., Corley, D. G., ... Williams, D. E. (1989). Novel Cytotoxins and Fungicides from Blue-Green-Algae and Marine Animals Possessing Algal Symbionts. Pure and Applied Chemistry, 61(3), 521-524. doi: 10.1351/pac198961030521