Xue, D., Zou, H., Qiu, Y., Lv, W., Madden, M. D., Xu, M., Lian, X., Pulliam, C., Older, E. A., Hou, L., Campbell, A., De Rond, T., Awakawa, T., Yuan, C., Moore, B. S., & Li, J. (2025). Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis. Nature Chemistry. https://doi.org/10.1038/s41557-025-01833-9

Adak, S., Calderone, L. A., Krueger, A., Pandelia, M.-E., & Moore, B. S. (2025). Single-Enzyme Conversion of Tryptophan to Skatole and Cyanide Expands the Mechanistic Competence of Diiron Oxidases. Journal of the American Chemical Society, 147(8), 6326–6331. https://doi.org/10.1021/jacs.4c14573

Ledoux, J.-B., Gomez-Garrido, J., Cruz, F., Camara Ferreira, F., Matos, A., Sarropoulou, X., Ramirez-Calero, S., Aurelle, D., Lopez-Sendino, P., Grayson, N. E., Moore, B. S., Antunes, A., Aguilera, L., Gut, M., Salces-Ortiz, J., Fernández, R., Linares, C., Garrabou, J., & Alioto, T. (2025). Chromosome-Level Genome Assembly and Annotation of Corallium rubrum : A Mediterranean Coral Threatened by Overharvesting and Climate Change. Genome Biology and Evolution, 17(2), evae253. https://doi.org/10.1093/gbe/evae253

Brunson, J. K., Thukral, M., Ryan, J. P., Anderson, C. R., Kolody, B. C., James, C. C., Chavez, F. P., Leaw, C. P., Rabines, A. J., Venepally, P., Fussy, Z., Zheng, H., Kudela, R. M., Smith, G. J., Moore, B. S., & Allen, A. E. (2024). Molecular forecasting of domoic acid during a pervasive toxic diatom bloom. Proceedings of the National Academy of Sciences, 121(40). https://doi.org/10.1073/pnas.2319177121

Adak, S., Ye, N., Calderone, L. A., Duan, M., Lubeck, W., Schäfer, R. J. B., Lukowski, A. L., Houk, K. N., Pandelia, M.-E., Drennan, C. L., & Moore, B. S. (2024). A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile. Nature Chemistry. https://doi.org/10.1038/s41557-024-01603-z

Fallon, T. R., Shende, V. V., Wierzbicki, I. H., Pendleton, A. L., Watervoot, N. F., Auber, R. P., Gonzalez, D. J., Wisecaver, J. H., & Moore, B. S. (2024). Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins. Science, 385(6709), 671–678. https://doi.org/10.1126/science.ado3290

Love, A. C., Purdy, T. N., Hubert, F. M., Kirwan, E. J., Holland, D. C., & Moore, B. S. (2024). Discovery of Latent Cannabichromene Cyclase Activity in Marine Bacterial Flavoenzymes. ACS Synthetic Biology, acssynbio.4c00051. https://doi.org/10.1021/acssynbio.4c00051

Steele, T. S., Burkhardt, I., Moore, M. L., De Rond, T., Bone, H. K., Barry, K., Bunting, V. M., Grimwood, J., Handley, L. H., Rajasekar, S., Talag, J., Michael, T. P., & Moore, B. S. (2024). Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases. ACS Chemical Biology, 19(1), 185–192. https://doi.org/10.1021/acschembio.3c00627

Sneed, J. M., Demko, A. M., Miller, M. W., Yi, D., Moore, B. S., Agarwal, V., & Paul, V. J. (2024). Coral settlement induction by tetrabromopyrrole is widespread among Caribbean corals and compound specific. Frontiers in Marine Science, 10, 1298518. https://doi.org/10.3389/fmars.2023.1298518

Burkhardt, I., Dürr, L., Grayson, N. E., & Moore, B. S. (2024). Methods for the discovery and characterization of octocoral terpene cyclases. In Methods in Enzymology (Vol. 699, pp. 343–371). Elsevier. https://doi.org/10.1016/bs.mie.2024.02.011

Shende, V. V., Bauman, K. D., & Moore, B. S. (2024). The shikimate pathway: gateway to metabolic diversity. Natural Product Reports, 10.1039.D3NP00037K. https://doi.org/10.1039/D3NP00037K

Zou, X., Hui, Z., Shepherd, R. A., Zhao, S., Wu, Y., Shen, Z., Pang, C., Zhou, S., Yu, Z., Zhou, J., Moore, B. S., Sanchez, L. M., & Tang, X. (2023). Unveiling a CAAX Protease‐Like Protein Involved in Didemnin Drug Maturation and Secretion. Advanced Science, 2306044. https://doi.org/10.1002/advs.202306044

Alker, A. T., Farrell, M. V., Demko, A. M., Purdy, T. N., Adak, S., Moore, B. S., Sneed, J. M., Paul, V. J., & Shikuma, N. J. (2023). Linking bacterial tetrabromopyrrole biosynthesis to coral metamorphosis. ISME Communications, 3(1), 98. https://doi.org/10.1038/s43705-023-00309-6

Lukowski, A. L., Hubert, F. M., Ngo, T.-E., Avalon, N. E., Gerwick, W. H., & Moore, B. S. (2023). Enzymatic Halogenation of Terminal Alkynes. Journal of the American Chemical Society, 145(34), 18716–18721. https://doi.org/10.1021/jacs.3c05750

Alker, A. T., Farrell, M. V., Aspiras, A. E., Dunbar, T. L., Fedoriouk, A., Jones, J. E., Mikhail, S. R., Salcedo, G. Y., Moore, B. S., & Shikuma, N. J. (2023). A modular plasmid toolkit applied in marine bacteria reveals functional insights during bacteria-stimulated metamorphosis. MBio, e01502-23. https://doi.org/10.1128/mbio.01502-23

Cordoza, J. L., Chen, P. Y.-T., Blaustein, L. R., Lima, S. T., Fiore, M. F., Chekan, J. R., Moore, B. S., & McKinnie, S. M. K. (2023). Mechanistic and Structural Insights into a Divergent PLP-Dependent l -Enduracididine Cyclase from a Toxic Cyanobacterium. ACS Catalysis, 13(14), 9817–9828. https://doi.org/10.1021/acscatal.3c01294

Wilson, K., De Rond, T., Burkhardt, I., Steele, T. S., Schäfer, R. J. B., Podell, S., Allen, E. E., & Moore, B. S. (2023). Terpene biosynthesis in marine sponge animals. Proceedings of the National Academy of Sciences, 120(9), e2220934120. https://doi.org/10.1073/pnas.2220934120

Shin, Y.-H., Im, J. H., Kang, I., Kim, E., Jang, S. C., Cho, E., Shin, D., Hwang, S., Du, Y. E., Huynh, T.-H., Ko, K., Ko, Y.-J., Nam, S.-J., Awakawa, T., Lee, J., Hong, S., Abe, I., Moore, B. S., Fenical, W., … Oh, D.-C. (2023). Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams. Journal of the American Chemical Society, 145(3), 1886–1896. https://doi.org/10.1021/jacs.2c11527

Wisecaver, J. H., Auber, R. P., Pendleton, A. L., Watervoort, N. F., Fallon, T. R., Riedling, O. L., Manning, S. R., Moore, B. S., & Driscoll, W. W. (2023). Extreme genome diversity and cryptic speciation in a harmful algal-bloom-forming eukaryote. Current Biology, 33(11), 2246-2259.e8. https://doi.org/10.1016/j.cub.2023.05.003

Schäfer, R. J. B., Wilson, K., Biedermann, M., Moore, B. S., Sieber, S., & Wennemers, H. (2022). Identification of Isonitrile‐Containing Natural Products in Complex Biological Matrices through Ligation with Chlorooximes. Chemistry – A European Journal. https://doi.org/10.1002/chem.202203277

Chen, P. Y.-T., Adak, S., Chekan, J. R., Liscombe, D. K., Miyanaga, A., Bernhardt, P., Diethelm, S., Fielding, E. N., George, J. H., Miles, Z. D., Murray, L. A. M., Steele, T. S., Winter, J. M., Noel, J. P., & Moore, B. S. (2022). Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry, 61(17), 1844–1852. https://doi.org/10.1021/acs.biochem.2c00338

Lima, S. T., Fallon, T. R., Cordoza, J. L., Chekan, J. R., Delbaje, E., Hopiavuori, A. R., Alvarenga, D. O., Wood, S. M., Luhavaya, H., Baumgartner, J. T., Dörr, F. A., Etchegaray, A., Pinto, E., McKinnie, S. M. K., Fiore, M. F., & Moore, B. S. (2022). Biosynthesis of Guanitoxin Enables Global Environmental Detection in Freshwater Cyanobacteria. Journal of the American Chemical Society, 144(21), 9372–9379. https://doi.org/10.1021/jacs.2c01424

Burkhardt, I., de Rond, T., Chen, P. Y. T., & Moore, B. S. (2022). Ancient plant-like terpene biosynthesis in corals. Nature Chemical Biology, 18(6), 664-+. https://doi.org/10.1038/s41589-022-01026-2

Bauman, K. D., Shende, V. V., Chen, P. Y. T., Trivella, D. B. B., Gulder, T. A. M., Vellalath, S., Romo, D., & Moore, B. S. (2022). Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead. Nature Chemical Biology, 25. https://doi.org/10.1038/s41589-022-00993-w

Purdy, T. N., Moore, B. S., & Lukowski, A. L. (2022). Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis. Journal of Natural Products, 85(3), 688–701. https://doi.org/10.1021/acs.jnatprod.1c01026

Adak, S., Lukowski, A. L., Schafer, R. J. B., & Moore, B. S. (2022). From tryptophan to toxin: Nature’s convergent biosynthetic strategy to aetokthonotoxin. Journal of the American Chemical Society, 144(7), 2861–2866. https://doi.org/10.1021/jacs.1c12778

Steele, T. S., Brunson, J. K., Maeno, Y., Terada, R., Allen, A. E., Yotsu-Yamashita, M., Chekan, J. R., & Moore, B. S. (2022). Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production. Proceedings of the National Academy of Sciences of the United States of America, 119(6). https://doi.org/10.1073/pnas.2117407119

Yahiaoui, O., Murray, L. A. M., Zhao, F. Y., Moore, B. S., Houk, K. N., Liu, F., & George, J. H. (2022). A Diazo-Hooker reaction, inspired by the biosynthesis of azamerone. Organic Letters, 6. https://doi.org/10.1021/acs.orglett.1c03810

Klau, L. J., Podell, S., Creamer, K. E., Demko, A. M., Singh, H. W., Allen, E. E., Moore, B. S., Ziemert, N., Letzel, A. C., & Jensen, P. R. (2022). The Natural Product Domain Seeker version 2 (NaPDoS2) webtool relates ketosynthase phylogeny to biosynthetic function. Journal of Biological Chemistry, 298(10), 102480. https://doi.org/10.1016/j.jbc.2022.102480

Zheng, J., Antrobus, S., Feng, W., Purdy, T. N., Moore, B. S., & Pessah, I. N. (2021). Marine and Anthropogenic Bromopyrroles Alter Cellular Ca2+ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca2+-ATPase. Environmental Science & Technology, 55(23), 16023–16033. https://doi.org/10.1021/acs.est.1c05214

Bauman, K. D., Butler, K. S., Moore, B. S., & Chekan, J. R. (2021). Genome mining methods to discover bioactive natural products. Natural Product Reports, 38(11), 2100–2129. https://doi.org/10.1039/d1np00032b

Daniels, P. N., Lee, H., Splain, R. A., Ting, C. P., Zhu, L. Y., Zhao, X. L., Moore, B. S., & van der Donk, W. A. (2021). A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor. Nature Chemistry, 10. https://doi.org/10.1038/s41557-021-00802-2

Medema, M. H., de Rond, T., & Moore, B. S. (2021). Mining genomes to illuminate the specialized chemistry of life. Nature Reviews Genetics, 19. https://doi.org/10.1038/s41576-021-00363-7

de Rond, T., Asay, J. E., & Moore, B. S. (2021). Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase. Nature Chemical Biology, 12. https://doi.org/10.1038/s41589-021-00808-4

Purdy, T. N., Kim, M. C., Cullum, R., Fenical, W., & Moore, B. S. (2021). Discovery and biosynthesis of tetrachlorizine reveals enzymatic benzylic dehydrogenation via an ortho-quinone methide. Journal of the American Chemical Society, 143(10), 3682–3686. https://doi.org/10.1021/jacs.0c12415

Adak, S., & Moore, B. S. (2021). Cryptic halogenation reactions in natural product biosynthesis. Natural Product Reports. https://doi.org/10.1039/d1np00010a

Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., … van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. https://doi.org/10.1038/s41589-020-00724-z

Kudo, Y., Awakawa, T., Du, Y. L., Jordan, P. A., Creamer, K. E., Jensen, P. R., Linington, R. G., Ryan, K. S., & Moore, B. S. (2020). Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products. Acs Chemical Biology, 15(12), 3253–3261. https://doi.org/10.1021/acschembio.0c00824

Chekan, J. R., Fallon, T. R., & Moore, B. S. (2020). Biosynthesis of marine toxins. Current Opinion in Chemical Biology, 59, 119–129. https://doi.org/10.1016/j.cbpa.2020.06.009

Murray, L. A. M., McKinnie, S. M. K., Moore, B. S., & George, J. H. (2020). Meroterpenoid natural products fromStreptomycesbacteria - the evolution of chemoenzymatic syntheses. Natural Product Reports, 37(10), 1334–1366. https://doi.org/10.1039/d0np00018c

Alker, A. T., Delherbe, N., Purdy, T. N., Moore, B. S., & Shikuma, N. J. (2020). Genetic examination of the marine bacteriumPseudoalteromonas luteoviolaceaand effects of its metamorphosis-inducing factors. Environmental Microbiology. https://doi.org/10.1111/1462-2920.15211

Podell, S., Blanton, J. M., Oliver, A., Schorn, M. A., Agarwal, V., Biggs, J. S., Moore, B. S., & Allen, E. E. (2020). A genomic view of trophic and metabolic diversity in clade-specific Lamellodysidea sponge microbiomes. Microbiome, 8. https://doi.org/10.21203/rs.2.17204/v1

Zhang, J. J., & Moore, B. S. (2020). Site-directed mutagenesis of large biosynthetic gene clusters via oligonucleotide recombineering and CRISPR/Cas9 targeting. Acs Synthetic Biology, 9(7), 1917–1922. https://doi.org/10.1021/acssynbio.0c00265

Chekan, O. R., McKinnie, S. M. K., Noel, J. P., & Moore, B. S. (2020). Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12799–12805. https://doi.org/10.1073/pnas.2001325117

Sigrist, R., Luhavaya, H., McKinnie, S. M. K., da Silva, A. F., Jurberg, I. D., Moore, B. S., & de Oliveira, L. G. (2020). Nonlinear biosynthetic assembly of alpiniamide by a hybrid cis/trans-AT PKS-NRPS. Acs Chemical Biology, 15(4), 1067–1077. https://doi.org/10.1021/acschembio.0c00081

Tang, X. Y., Kudo, Y., Baker, J. L., LaBonte, S., Jordan, P. A., McKinnie, S. M. K., Guo, J., Huan, T., Moore, B. S., & Edlund, A. (2020). Cariogenic Streptococcus mutans produces tetramic acid strain-specific antibiotics that impair commensal colonization. Acs Infectious Diseases, 6(4), 563–571. https://doi.org/10.1021/acsinfecdis.9b00365

Fiore, M. F., de Lima, S. T., Carmichael, W. W., McKinnie, S. M. K., Chekan, J. R., & Moore, B. S. (2020). Guanitoxin, re-naming a cyanobacterial organophosphate toxin. Harmful Algae, 92. https://doi.org/10.1016/j.hal.2019.101737

Zhang, J. J., Tang, X. Y., Huan, T., Ross, A. C., & Moore, B. S. (2020). Pass-back chain extension expands multimodular assembly line biosynthesis. Nature Chemical Biology, 16(1), 42-+. https://doi.org/10.1038/s41589-019-0385-4

Chekan, J. R., Lee, G. Y., El Gamal, A., Purdy, T. N., Houk, K. N., & Moore, B. S. (2019). Bacterial tetrabromopyrrole debrominase shares a reductive dehalogenation strategy with human thyroid deiodinase. Biochemistry, 58(52), 5329–5338. https://doi.org/10.1021/acs.biochem.9b00318

Li, Z. R., Li, J., Cai, W. L., Lai, J. Y. H., McKinnie, S. M. K., Zhang, W. P., Moore, B. S., Zhang, W. J., & Qian, P. Y. (2019). Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nature Chemistry, 11(10), 880–889. https://doi.org/10.1038/s41557-019-0317-7