Publications


Steele, T. S., Burkhardt, I., Moore, M. L., De Rond, T., Bone, H. K., Barry, K., Bunting, V. M., Grimwood, J., Handley, L. H., Rajasekar, S., Talag, J., Michael, T. P., & Moore, B. S. (2024). Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases. ACS Chemical Biology, 19(1), 185–192. https://doi.org/10.1021/acschembio.3c00627
Sneed, J. M., Demko, A. M., Miller, M. W., Yi, D., Moore, B. S., Agarwal, V., & Paul, V. J. (2024). Coral settlement induction by tetrabromopyrrole is widespread among Caribbean corals and compound specific. Frontiers in Marine Science, 10, 1298518. https://doi.org/10.3389/fmars.2023.1298518
Shende, V. V., Bauman, K. D., & Moore, B. S. (2024). The shikimate pathway: gateway to metabolic diversity. Natural Product Reports, 10.1039.D3NP00037K. https://doi.org/10.1039/D3NP00037K
Zou, X., Hui, Z., Shepherd, R. A., Zhao, S., Wu, Y., Shen, Z., Pang, C., Zhou, S., Yu, Z., Zhou, J., Moore, B. S., Sanchez, L. M., & Tang, X. (2023). Unveiling a CAAX Protease‐Like Protein Involved in Didemnin Drug Maturation and Secretion. Advanced Science, 2306044. https://doi.org/10.1002/advs.202306044
Alker, A. T., Farrell, M. V., Demko, A. M., Purdy, T. N., Adak, S., Moore, B. S., Sneed, J. M., Paul, V. J., & Shikuma, N. J. (2023). Linking bacterial tetrabromopyrrole biosynthesis to coral metamorphosis. ISME Communications, 3(1), 98. https://doi.org/10.1038/s43705-023-00309-6
Lukowski, A. L., Hubert, F. M., Ngo, T.-E., Avalon, N. E., Gerwick, W. H., & Moore, B. S. (2023). Enzymatic Halogenation of Terminal Alkynes. Journal of the American Chemical Society, 145(34), 18716–18721. https://doi.org/10.1021/jacs.3c05750
Alker, A. T., Farrell, M. V., Aspiras, A. E., Dunbar, T. L., Fedoriouk, A., Jones, J. E., Mikhail, S. R., Salcedo, G. Y., Moore, B. S., & Shikuma, N. J. (2023). A modular plasmid toolkit applied in marine bacteria reveals functional insights during bacteria-stimulated metamorphosis. MBio, e01502-23. https://doi.org/10.1128/mbio.01502-23
Cordoza, J. L., Chen, P. Y.-T., Blaustein, L. R., Lima, S. T., Fiore, M. F., Chekan, J. R., Moore, B. S., & McKinnie, S. M. K. (2023). Mechanistic and Structural Insights into a Divergent PLP-Dependent l -Enduracididine Cyclase from a Toxic Cyanobacterium. ACS Catalysis, 13(14), 9817–9828. https://doi.org/10.1021/acscatal.3c01294
Wilson, K., De Rond, T., Burkhardt, I., Steele, T. S., Schäfer, R. J. B., Podell, S., Allen, E. E., & Moore, B. S. (2023). Terpene biosynthesis in marine sponge animals. Proceedings of the National Academy of Sciences, 120(9), e2220934120. https://doi.org/10.1073/pnas.2220934120
Shin, Y.-H., Im, J. H., Kang, I., Kim, E., Jang, S. C., Cho, E., Shin, D., Hwang, S., Du, Y. E., Huynh, T.-H., Ko, K., Ko, Y.-J., Nam, S.-J., Awakawa, T., Lee, J., Hong, S., Abe, I., Moore, B. S., Fenical, W., … Oh, D.-C. (2023). Genomic and Spectroscopic Signature-Based Discovery of Natural Macrolactams. Journal of the American Chemical Society, 145(3), 1886–1896. https://doi.org/10.1021/jacs.2c11527
Wisecaver, J. H., Auber, R. P., Pendleton, A. L., Watervoort, N. F., Fallon, T. R., Riedling, O. L., Manning, S. R., Moore, B. S., & Driscoll, W. W. (2023). Extreme genome diversity and cryptic speciation in a harmful algal-bloom-forming eukaryote. Current Biology, 33(11), 2246-2259.e8. https://doi.org/10.1016/j.cub.2023.05.003
Schäfer, R. J. B., Wilson, K., Biedermann, M., Moore, B. S., Sieber, S., & Wennemers, H. (2022). Identification of Isonitrile‐Containing Natural Products in Complex Biological Matrices through Ligation with Chlorooximes. Chemistry – A European Journal. https://doi.org/10.1002/chem.202203277
Chen, P. Y.-T., Adak, S., Chekan, J. R., Liscombe, D. K., Miyanaga, A., Bernhardt, P., Diethelm, S., Fielding, E. N., George, J. H., Miles, Z. D., Murray, L. A. M., Steele, T. S., Winter, J. M., Noel, J. P., & Moore, B. S. (2022). Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry, 61(17), 1844–1852. https://doi.org/10.1021/acs.biochem.2c00338
Lima, S. T., Fallon, T. R., Cordoza, J. L., Chekan, J. R., Delbaje, E., Hopiavuori, A. R., Alvarenga, D. O., Wood, S. M., Luhavaya, H., Baumgartner, J. T., Dörr, F. A., Etchegaray, A., Pinto, E., McKinnie, S. M. K., Fiore, M. F., & Moore, B. S. (2022). Biosynthesis of Guanitoxin Enables Global Environmental Detection in Freshwater Cyanobacteria. Journal of the American Chemical Society, 144(21), 9372–9379. https://doi.org/10.1021/jacs.2c01424
Burkhardt, I., de Rond, T., Chen, P. Y. T., & Moore, B. S. (2022). Ancient plant-like terpene biosynthesis in corals. Nature Chemical Biology, 18(6), 664-+. https://doi.org/10.1038/s41589-022-01026-2
Bauman, K. D., Shende, V. V., Chen, P. Y. T., Trivella, D. B. B., Gulder, T. A. M., Vellalath, S., Romo, D., & Moore, B. S. (2022). Enzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead. Nature Chemical Biology, 25. https://doi.org/10.1038/s41589-022-00993-w
Purdy, T. N., Moore, B. S., & Lukowski, A. L. (2022). Harnessing ortho-Quinone Methides in Natural Product Biosynthesis and Biocatalysis. Journal of Natural Products, 85(3), 688–701. https://doi.org/10.1021/acs.jnatprod.1c01026
Adak, S., Lukowski, A. L., Schafer, R. J. B., & Moore, B. S. (2022). From tryptophan to toxin: Nature’s convergent biosynthetic strategy to aetokthonotoxin. Journal of the American Chemical Society, 144(7), 2861–2866. https://doi.org/10.1021/jacs.1c12778
Steele, T. S., Brunson, J. K., Maeno, Y., Terada, R., Allen, A. E., Yotsu-Yamashita, M., Chekan, J. R., & Moore, B. S. (2022). Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production. Proceedings of the National Academy of Sciences of the United States of America, 119(6). https://doi.org/10.1073/pnas.2117407119
Yahiaoui, O., Murray, L. A. M., Zhao, F. Y., Moore, B. S., Houk, K. N., Liu, F., & George, J. H. (2022). A Diazo-Hooker reaction, inspired by the biosynthesis of azamerone. Organic Letters, 6. https://doi.org/10.1021/acs.orglett.1c03810
Klau, L. J., Podell, S., Creamer, K. E., Demko, A. M., Singh, H. W., Allen, E. E., Moore, B. S., Ziemert, N., Letzel, A. C., & Jensen, P. R. (2022). The Natural Product Domain Seeker version 2 (NaPDoS2) webtool relates ketosynthase phylogeny to biosynthetic function. Journal of Biological Chemistry, 298(10), 102480. https://doi.org/10.1016/j.jbc.2022.102480
Zheng, J., Antrobus, S., Feng, W., Purdy, T. N., Moore, B. S., & Pessah, I. N. (2021). Marine and Anthropogenic Bromopyrroles Alter Cellular Ca2+ Dynamics of Murine Cortical Neuronal Networks by Targeting the Ryanodine Receptor and Sarco/Endoplasmic Reticulum Ca2+-ATPase. Environmental Science & Technology, 55(23), 16023–16033. https://doi.org/10.1021/acs.est.1c05214
Bauman, K. D., Butler, K. S., Moore, B. S., & Chekan, J. R. (2021). Genome mining methods to discover bioactive natural products. Natural Product Reports, 38(11), 2100–2129. https://doi.org/10.1039/d1np00032b
Daniels, P. N., Lee, H., Splain, R. A., Ting, C. P., Zhu, L. Y., Zhao, X. L., Moore, B. S., & van der Donk, W. A. (2021). A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor. Nature Chemistry, 10. https://doi.org/10.1038/s41557-021-00802-2
Medema, M. H., de Rond, T., & Moore, B. S. (2021). Mining genomes to illuminate the specialized chemistry of life. Nature Reviews Genetics, 19. https://doi.org/10.1038/s41576-021-00363-7
de Rond, T., Asay, J. E., & Moore, B. S. (2021). Co-occurrence of enzyme domains guides the discovery of an oxazolone synthetase. Nature Chemical Biology, 12. https://doi.org/10.1038/s41589-021-00808-4
Purdy, T. N., Kim, M. C., Cullum, R., Fenical, W., & Moore, B. S. (2021). Discovery and biosynthesis of tetrachlorizine reveals enzymatic benzylic dehydrogenation via an ortho-quinone methide. Journal of the American Chemical Society, 143(10), 3682–3686. https://doi.org/10.1021/jacs.0c12415
Adak, S., & Moore, B. S. (2021). Cryptic halogenation reactions in natural product biosynthesis. Natural Product Reports. https://doi.org/10.1039/d1np00010a
Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., … van der Hooft, J. J. J. (2021). A community resource for paired genomic and metabolomic data mining. Nature Chemical Biology. https://doi.org/10.1038/s41589-020-00724-z
Kudo, Y., Awakawa, T., Du, Y. L., Jordan, P. A., Creamer, K. E., Jensen, P. R., Linington, R. G., Ryan, K. S., & Moore, B. S. (2020). Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products. Acs Chemical Biology, 15(12), 3253–3261. https://doi.org/10.1021/acschembio.0c00824
Chekan, J. R., Fallon, T. R., & Moore, B. S. (2020). Biosynthesis of marine toxins. Current Opinion in Chemical Biology, 59, 119–129. https://doi.org/10.1016/j.cbpa.2020.06.009
Murray, L. A. M., McKinnie, S. M. K., Moore, B. S., & George, J. H. (2020). Meroterpenoid natural products fromStreptomycesbacteria - the evolution of chemoenzymatic syntheses. Natural Product Reports, 37(10), 1334–1366. https://doi.org/10.1039/d0np00018c
Alker, A. T., Delherbe, N., Purdy, T. N., Moore, B. S., & Shikuma, N. J. (2020). Genetic examination of the marine bacteriumPseudoalteromonas luteoviolaceaand effects of its metamorphosis-inducing factors. Environmental Microbiology. https://doi.org/10.1111/1462-2920.15211
Podell, S., Blanton, J. M., Oliver, A., Schorn, M. A., Agarwal, V., Biggs, J. S., Moore, B. S., & Allen, E. E. (2020). A genomic view of trophic and metabolic diversity in clade-specific Lamellodysidea sponge microbiomes. Microbiome, 8. https://doi.org/10.21203/rs.2.17204/v1
Zhang, J. J., & Moore, B. S. (2020). Site-directed mutagenesis of large biosynthetic gene clusters via oligonucleotide recombineering and CRISPR/Cas9 targeting. Acs Synthetic Biology, 9(7), 1917–1922. https://doi.org/10.1021/acssynbio.0c00265
Chekan, O. R., McKinnie, S. M. K., Noel, J. P., & Moore, B. S. (2020). Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an N-prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America, 117(23), 12799–12805. https://doi.org/10.1073/pnas.2001325117
Sigrist, R., Luhavaya, H., McKinnie, S. M. K., da Silva, A. F., Jurberg, I. D., Moore, B. S., & de Oliveira, L. G. (2020). Nonlinear biosynthetic assembly of alpiniamide by a hybrid cis/trans-AT PKS-NRPS. Acs Chemical Biology, 15(4), 1067–1077. https://doi.org/10.1021/acschembio.0c00081
Tang, X. Y., Kudo, Y., Baker, J. L., LaBonte, S., Jordan, P. A., McKinnie, S. M. K., Guo, J., Huan, T., Moore, B. S., & Edlund, A. (2020). Cariogenic Streptococcus mutans produces tetramic acid strain-specific antibiotics that impair commensal colonization. Acs Infectious Diseases, 6(4), 563–571. https://doi.org/10.1021/acsinfecdis.9b00365
Fiore, M. F., de Lima, S. T., Carmichael, W. W., McKinnie, S. M. K., Chekan, J. R., & Moore, B. S. (2020). Guanitoxin, re-naming a cyanobacterial organophosphate toxin. Harmful Algae, 92. https://doi.org/10.1016/j.hal.2019.101737
Zhang, J. J., Tang, X. Y., Huan, T., Ross, A. C., & Moore, B. S. (2020). Pass-back chain extension expands multimodular assembly line biosynthesis. Nature Chemical Biology, 16(1), 42-+. https://doi.org/10.1038/s41589-019-0385-4
Chekan, J. R., Lee, G. Y., El Gamal, A., Purdy, T. N., Houk, K. N., & Moore, B. S. (2019). Bacterial tetrabromopyrrole debrominase shares a reductive dehalogenation strategy with human thyroid deiodinase. Biochemistry, 58(52), 5329–5338. https://doi.org/10.1021/acs.biochem.9b00318
Li, Z. R., Li, J., Cai, W. L., Lai, J. Y. H., McKinnie, S. M. K., Zhang, W. P., Moore, B. S., Zhang, W. J., & Qian, P. Y. (2019). Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. Nature Chemistry, 11(10), 880–889. https://doi.org/10.1038/s41557-019-0317-7
Zhang, J. J., Tang, X. Y., & Moore, B. S. (2019). Genetic platforms for heterologous expression of microbial natural products. Natural Product Reports, 36(9), 1313–1332. https://doi.org/10.1039/c9np00025a
Valiadi, M., de Rond, T., Amorim, A., Gittins, J. R., Gubili, C., Moore, B. S., Iglesias-Rodriguez, M. D., & Latz, M. I. (2019). Molecular and biochemical basis for the loss of bioluminescence in the dinoflagellate Noctiluca scintillans along the west coast of the USA. Limnology and Oceanography. https://doi.org/10.1002/lno.11309
Schorn, M. A., Jordan, P. A., Podell, S., Blanton, J. M., Agarwal, V., Biggs, J. S., Allen, E. E., & Moore, B. S. (2019). Comparative genomics of cyanobacterial symbionts reveals distinct, specialized metabolism in tropical Dysideidae sponges. Mbio, 10. https://doi.org/10.1128/mBio.00821-19
Chekan, J. R., McKinnie, S. M. K., Moore, M. L., Poplawski, S. G., Michael, T. P., & Moore, B. S. (2019). Scalable biosynthesis of the seaweed neurochemical, kainic acid. Angewandte Chemie-International Edition, 58(25), 8454–8457. https://doi.org/10.1002/anie.201902910
Luhavaya, H., Sigrist, R., Chekan, J. R., McKinnie, S. M. K., & Moore, B. S. (2019). Biosynthesis of l-4-chlorokynurenine, an antidepressant prodrug and a non-proteinogenic amino acid found in lipopeptide antibiotics. Angewandte Chemie-International Edition, 58(25), 8394–8399. https://doi.org/10.1002/anie.201901571
Busch, J., Agarwal, V., Schorn, M., Machado, H., Moore, B. S., Rouse, G. W., Gram, L., & Jensen, P. R. (2019). Diversity and distribution of the bmp gene cluster and its Polybrominated products in the genus Pseudoalteromonas. Environmental Microbiology, 21(5), 1575–1585. https://doi.org/10.1111/1462-2920.14532
Bauman, K. D., Li, J., Murata, K., Mantovani, S. M., Dahesh, S., Nizet, V., Luhavaya, H., & Moore, B. S. (2019). Refactoring the cryptic streptophenazine biosynthetic gene cluster unites phenazine, polyketide, and nonribosomal peptide biochemistry. Cell Chemical Biology, 26(5), 724-+. https://doi.org/10.1016/j.chembiol.2019.02.004
Walsh, C. T., & Moore, B. S. (2019). Enzymatic cascade reactions in biosynthesis. Angewandte Chemie-International Edition, 58(21), 6846–6879. https://doi.org/10.1002/anie.201807844